Bleeding Disorders

Question 1

vWF inheritance pattern

Answer 1

Autosomal dominant

(variable expressivity, but usually a mild bleeding disorder)

Question 2

Gallstones/malignancy in biliary tree/head of pancreas can cause which vitamin deficiency ?

Answer 2

Vitamin K

Requires biliary salts for absorption

Question 3

Example of a Vitamin K antagonist ?

Answer 3

Warfarin

Question 4

Haemophilia A =

Answer 4

Factor VIII deficiency

Question 4

Haemophilia B =

Answer 4

Factor IX deficiency

Question 5

Haemophilia =

Answer 5

An X-linked, hereditary disorder in which abnormally prolonged bleeding recurs episodically at one or a few sites on each occasion

Question 6

Features of severe haemophilia

Answer 6

• Recurrent Haemarthroses
• Recurrent soft tissue bleeds bruising in toddlers
• Prolonged bleeding after dental extractions, surgery and invasive procedures