Bladder Disorders Flashcards

1
Q

Urinary Incontinence RFs in men

A
  • major depression
  • incr age
  • HTN
  • BPH
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2
Q

Urinary Incontinence RFs in women

A

Parity, vaginal delivery, increased BMI, DM, family hx, hormone replacement, depression, anxiety

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3
Q

Meds that causes Urinary Incontinence

A
  • antiHTN medications
  • pain relievers (opioids & COX-2 inhibitors)
  • muscle relaxants
  • psychiatric medicines
  • antihistamines
  • anticholinergics
  • Alcohol
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4
Q

What antihypertensive meds cause urinary incontinence

A
  • diuretics
  • alpha blockers
  • ACE inhibitors
  • CCB
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5
Q

What psychiatric meds cause urinary incontinence

A
  • antidepressants
  • antipsychotics
  • sedatives & hypnotics
  • antiparkinson agents
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6
Q

Causes of Urinary Incontinence w/o specific urogenital cause

A
  • Delirium
  • Infx
  • Atrophic urethritis/vaginitis
  • Meds
  • Psychiatric causes (depression)
  • Excessive urinary output (DM, hyperCa++, CHF)
  • Restricted mobility
  • Stool impaction
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7
Q

Urinary Incontinence Urge pathophys

A

strong, and often immediate, urge to void followed by an involuntary loss of urine
suggests detrusor overactivity due to irritation in bladder or neurogenic causes
more common in men

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8
Q

Urinary Incontinence Stress pathophys

A

involuntary loss of urine during physical exertion, effort, coughing, or sneezing, presumably due to elevated intra-abdominal pressure
Much more common in women

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9
Q

Urinary Incontinence Overflow pathophys

A

loss of urine associated with overdistention of the bladder. Patients complain of frequent or constant leakage or dribbling, or they may lose large amounts of urine without warning
Results from detrusor hypoactivity

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10
Q

Urinary Incontinence Functional pathophys

A

physical or cognitive impairments that interfere with continence even in patients with normal urinary tracts

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11
Q

Urinary Incontinence S/S

A
  • activity associated w/ leakage?
  • loss of small amount of urine during certain activities may suggest stress incontinence
    –> physical activity or incr intra-abdo pressure (coughing, sneezing, jumping, lifting, exercise)
    –> minimal activity, such as walking or rising from a chair
  • loss of urine preceded by sudden & severe desire to pass urine may suggest urge incontinence
  • In women, ask about pregnancy & childbirth hx
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12
Q

Urinary Incontinence Lifestyle Tx

A
  • Tx reversible causes
  • Lifestyle measures: limiting excessive fluid intake, avoiding caffeinated & alcoholic beverages, & attaining a healthy weight
  • Scheduled voiding or prompted voiding
  • Pelvic floor exercises
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13
Q

Urinary Incontinence Pharmacologic Tx

A
  • Anticholinergic/antimuscarinic meds for urge incontinence (Oxybutynin, Tolterodine)
  • Same med can be used for stress incontinence but does not work quite as well
  • Desmopressin (synthetic ADH) can be used to nocturia

Vaginal estrogen for vaginal atrophy

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14
Q

Urinary Incontinence s
Surgical Tx

A
  • Surgical decompression of the urethra for obstruction (BPH)
  • Bladder/urethral slings
  • Artificial sphincters
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15
Q

Overactive Bladder Tx

A

Anticholinergic/antimuscarinic medications are the drugs of choice for urge incontinence
- Oxybutynin
- Tolterodine

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16
Q

Cystocele RFs

A
  • Previous vaginal delivery
  • Advancing age
  • Menopause
  • Incr parity
  • Obesity
17
Q

Cystocele vaginal symp

A
  • sensation of or visible bulge or protrusion from vagina
  • pelvic pressure or heaviness
  • feeling of something “falling out” of vagina
18
Q

Cystocele Tx

A
  • Watchful waiting if asymp
  • Pelvic floor muscle exercises
  • Pessary
  • Surgical reconstruction
19
Q

Interstitial Cystitis RFs

A
  • Female
  • Caucasian
  • Age around 40yo
  • Depression
  • Other chronic pain syndromes
  • Recent UTI
  • h/o sexual abuse
20
Q

Interstitial Cystitis Tx

A
  • Amitriptyline
  • CCB
  • Elmiron (Pentosan polysulfate)
  • Intravesical tx w/ lidocaine, dimethyl sulfoxide, or heparin
21
Q

Uncomplicated Acute Cystitis RFs

A
  • sexual intercourse
  • spermicide use
  • new sex partner w/n past yr
  • previous UTI
22
Q

Other causes of uncomplicated acute cystitis:

A
  • Klebsiella pneumoniae
  • Enterococcus faecalis
  • Proteus mirabilis
  • Staph saprophyticus
  • Strep agalactiae(Group BStrep)
23
Q

What two things to we usually pay close attention to on a UA?

A

Leukocyte esterase & Nitrite

24
Q

Uncomplicated Acute Cystitis Tx

A
  • 1st line: Nitrofurantoin
  • TMP/SMX (Bactrim) if local resistance <20%
  • If those can’t be used–> Cipro or Levofloxacin
  • Augmentin or Cephalexin are okay
25
Q

How long do you take the Abx prescribed for uncomplicated acute cystitis?

A

3-5 days

26
Q

What can be given for symptomatic relief (pain) of uncomplicated acute cystitis?

A

Phenazopyridine (Azo) OTC

27
Q

How long do you take the med suggested for uncomplicated acute cystitis symptomatic tx?

A

2 days

28
Q

Complicated Acute Cystitis Outpt Tx

A
  • Fluoroquinolone (Levaquin or Cipro)
  • If known resistance, give 1 dose parenteral (IV/IM) agent then oral fluoroquinolone
  • If unable to take fluoroquinolone, give 1 dose parenteral agent, then Bactrim, Augmentin, or Cefdinir
29
Q

Complicated Acute Cystitis Inpt Tx

A
  • Ceftriaxone
    OR
  • Piperacillin-tazobactam (Zosyn)
30
Q

Bladder Cancer RFs

A
  • smoking
  • certain chemical exposures (chemical dyes, paint, metal, & petroleum)
  • HPV/gonorrhea
  • Previous pelvic radiation
31
Q

Non-muscle Invasive Bladder Cancer Tx

A

transurethral resection of bladder tumor
–> does of intravesicular chemo given w/n 24hrs

32
Q

5-year survival rate Bladder Cancer

A
  • 70% w/ localized dz
  • 35% w/ regional dz
  • 5% w/ distant stage dz
33
Q

Muscle Invasive Bladder Cancer Tx

A
  • Partial cystectomy
  • Complete cystectomy
  • Chemo
  • Immunotherapy