Blackout Flashcards
Define syncope.
A form of loss of consciousness in which hypoperfusion of the brain is the cause
List the four main mechanisms of syncope.
Reflex – caused by a primitive reflex that leads mammals to play dead. It causes a temporary drop in blood pressure.
Cardiac
Orthostatic
Cerebrovascular – non-cardiac structural causes of reduced cerebral perfusion (RARE)
How can the cardiac causes of syncope be further divided?
Arrhythmia
Outflow obstruction (e.g. aortic stenosis, HOCM)
Postural hypotension
What can cause orthostatic hypotension?
Blunting of the normal autonomic response to standing up (vasoconstriction + rise in heart rate)
It is most commonly due to drugs or autonomic neuropathy
What are some of the causes of syncope (that fall under the four mechanisms)?
Reflex Vasovagal syncope Other: carotid sinus hypersensitivity Cardiac Arrhythmias Outflow obstruction Orthostatic Drugs Dehydration Autonomic instability Baroreceptor dysfunction Cerebrovascular Vertebrobasilar insufficiency Subclavian steal syndrome Aortic dissection
List some non-syncopal causes of blackout.
Intoxication
Head trauma
Psychogenic (non-epileptic)
Epileptic seizure
What is the most common cause of blackout in:
Young
Middle-aged
Elderly
The young Vasovagal The middle-aged Vasovagal + arrhythmia The elderly Postural hypotension
Which classes of medications are commonly associated with orthostatic hypotension?
ACE inhibitors Diuretics Beta-blockers Alpha-blockers CCBs
List three questions that are important to ask about the event preceding the blackout.
Was there any WARNING?
Were there any PRECIPITATING FACTORS?
Was there any HEAD TRAUMA?
Which causes of collapse may be associated with symptoms preceding collapse?
Epileptic seizure – patients may experience a prodromal aura
Vasovagal – patients may experience vagal symptoms (e.g. sweating, pallor, nausea, dizziness)
Which causes of collapse tend to occur with no warning?
Cardiac causes
NOTE: arrhythmias may cause preceding palpitations
List some factors that may precipitate collapse and state the underlying cause of collapse that they are associated with.
Standing up – postural hypotension
Exercise – cardiac pathology (e.g. aortic stenosis, HOCM, long QT)
Head turning – carotid body hypersensitivity
Vigorous arm activity – subclavian steal syndrome
Vasovagal has many precipitants (e.g. fear, heat, standing for a long time)
List two questions that are important to ask about what happened during the collapse.
HOW LONG did the blackout last?
Was there any TONGUE-BITING, MOVEMENT OF LIMBS or INCONTINENCE of urine or faeces?
What feature of the collapse is pathognomonic with an epileptic seizure?
Tongue-biting
What question is important to ask about the state of the patient after the collapse?
Did the patient RECOVER SPONTANEOUSLY or were they CONFUSED afterwards?
List five key components that should be explored in the patient’s past medical history.
Previous episodes of collapse Diabetes Cardiac illness Peripheral vascular disease (ask about intermittent claudication because they may not have had a PVD diagnosis) Epilepsy Anaemia Psychiatric illness
List some important features of the drug history that help narrow the differential for collapse.
Insulin and other hypoglycaemics
Antihypertensives
Vasodilators
Anti-arrhythmics (paradoxically predisposes to arrhythmia)
Antidepressants (hypotension may be a side effect)
Warfarin and other anticoagulants
List some important features of the social history.
Alcohol
Use of stimulant recreational drugs (e.g. cocaine) – can cause tachyarrhythmia and drop cardiac output