Bisphosphonate: Alendronate Flashcards
Antiresorptive Agents - slow rate bone loss
1
Q
Bisphosphonate
MOA
A
It is incorporated into the bone matrix by forming tight complexes with calcium. And can last months and even up to years. High conc of the bisphosphonate inhibits the bone resorption activity of osteoclasts. It is ingested by osteoclast which has toxic effects causing osteoclast apoptosis
2
Q
Bisphosphonate
Abs/Distb/Elim
A
Given orally ( daily, weekly, monthly) or IV ( 3 months - yearly).
Short half-life in plasma - 6hrs
Long half life in bone - 10 years
3
Q
Bisphosphate
Clinical use
A
Postmenopausal osteoporosis
4
Q
Bisphosphonate
Adverse effects
A
GIT disturbance (particularly oesophagitis)
Bone pain
Osteonecrosis of jaw (rare) - with IV administration
