Biological Agent: Denosumab

Question 1

Denosumab
MOA

Answer 1

Monoclonal antibody that is a RANKL inhibitor. It prevents RANKL from binding with the osteoclasts precursor which reduces osteoclast formation, differentiation and survival

Question 2

Denosumab
Abs/Distrb/Elim

Answer 2

SQ every 6 months

Question 3

Denosumab
Clinical use

Answer 3

Treatment for osteoporosis
Patients unable to adhere to or who have contraindications to bisphosphonate

Question 4

Denosumab
Adverse Effets

Answer 4

Prior to treatment, those with risk factors for ONJ should get an dental exam