Bipolar science Flashcards
1
Q
Bipolar pathophysiology? [3]
A
Dendritic spine loss
Altered cellular connectivity
Neural plasticity
2
Q
What is the method of action of lithium (bipolar)?
A
~ Lithium modifies the production and turnover of neurotransmitters such as serotonin.
~ It is also thought to block dopamine receptors.
3
Q
What is the method of action of carbamazepine, valproate and lamotrigine in bipolar?
A
They affect sodium voltage channels, preventing action potential generation. The reduction in neuronal excitation helps manage the mania in bipolar.
