Bipolar Disorder Pharmacology Flashcards
Antipsychotics were excluded from this deck
1
Q
What is the MOA of benzodiazepines?
A
Binding of GABA is ↑ by benzodiazepine → ↑binding of GABA on GABA receptors on Cl- channels → Cl- channels open → ↑influx of Cl- ions → hyperpolarization → ↑inhibition
2
Q
When is benzodiazepines indicated?
A
Adjunctive to help pt relax and sleep better
3
Q
List 2 SEs of benzodiazepines
A
- CNS depression, sedation
- Cognitive & motor impairment
- Dependence / withdrawal
4
Q
Does benzodiazepine undergo hepatic metabolism?
A
Yes!
Note: both hepatic and renal impairment is a precaution for benzodiazepines
5
Q
What is the MOA of lithium?
A
- Normalise/ inhibits 2° messenger systems
- May ↓ PKC
- ↓ 5HT reuptake
- ↓ DA release
6
Q
Where is lithium indicated in?
A
Bipolar Disorder
* Mania / Depression
* Suicide Prevention, Maintenance
7
Q
True or false?
Lithium undergoes hepatic metabolism
A
False!
Is 100% renal clearance
8
Q
What are the SEs of lithium?
9
A
- Fine to coarse tremors
- Polyuria
- Hypothyroidism
- Cardiac (ECG changes),
- Nausea
- Fatigue
- Weight gain
- Cognitive impairment
- Diabetes insipidus
Commonly at >0/8mEq/L
