Bipolar disorder Flashcards

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1
Q

What would be a characteristic presentation of mania?

A

DIG FAST:

  • Distractibility
  • Irresponsibility
  • Grandiose delusions
  • Flight of ideas
  • Activity increase
  • Sleep deficit
  • Talkativeness
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2
Q

How do you differentiate between hypomania and mania?

A

DSM-4:

Hypomania:

  • At least 4 days
  • Clearly different from usual non-depressed mood
  • Change in functioning, uncharacteristic of patient when asymptomatic
  • Not severe enough to cause marked impairment in social/occupational functioning or hospitalistion
  • No psychotic features

Mania:

  • Lasts at least a week
  • Clearly different from usual non-depressed mood
  • Change in functioning, uncharacteristic of patient when asymptomatic
  • May be severe enough to warrant hospitalisation
  • May have psychotic features
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3
Q

How should an assessment be done on an intoxicated patient?

A
  • On-call psychiatry should assess the patient

- Request MHA assessment once patient is sober

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4
Q

What are the symptoms of delirium tremens?

A
  • Autonomic hyperactivity
  • Tachycardia
  • Fever
  • Insonmia
  • Anxiety
  • Hypertension
  • Perceptual distortions
  • Visual/tactile hallucinations (formication - insects crawling)
  • Fluctuating motor activity
  • Delirium
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5
Q

How is delirium tremens managed?

A
  • Benzodiazepine
    (Usually Chlorodiazepoxide)
  • Rehydrate with IV fluids and Pabrinex
    (Prevents Wernicke’s encephalopathy)

Once stable:
- Gain history of alcohol use

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6
Q

What is Wernicke’s encephalopathy?

A

Wernicke’s:

  • Acute neurological condition
  • Life threatening
  • Caused by thiamine deficiency
  • Can result in Korsakoff syndrome

Triad:

  • Opthalmoparesis with nystagmus
  • Ataxia
  • Confusion
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7
Q

What is Korsakoff syndrome?

A

Korsakoff:

  • Consequence of at least one episode of Wernicke’s
  • Preventable
  • Neuropsychiatric disorder
  • Memory disturbances
  • Deficits in anterograde and retrograde memory
  • Immediate memory is maintained
  • Patient’s can fabricate stories
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8
Q

What is the DSM-5 criteria for bipolar disorder?

A

Lows same as major depressive disorder

  • Hopeless and discouraged
  • Lack energy and focus
  • Eating changes
  • Sleeping changes

Also have manic episodes

  • Distinct period of elevated/irritable mood
  • Increased activity/energy
  • At least 1 week

Symptoms:

  • Inflated self-esteem and grandiosity
  • Decreased need for sleep
  • More talkative, pressured speech
  • Flight of ideas
  • Distractibility
  • Increase in goal-directed activity
  • High-risk behaviour
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9
Q

How does bipolar I present?

A
  • Strong lows lasting 2 weeks or more

- Major highs lasting at least 1 week

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10
Q

How does bipolar II present?

A
  • Strong lows lasting 2 weeks or more

- Smaller highs that are more hypomanic, lasting at least 4 days

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11
Q

How does cyclothymia present?

A
  • Milder lows AND highs

- Cycle between the two for at least 2 years

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12
Q

What is rapid cycling?

A

4 or more episodes of depression or mania within a year

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13
Q

What are mixed episodes?

A

Episodes that have both depressive and manic symptoms

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14
Q

What does lithium do?

A
  • Much better for manic episodes
  • Mood stabilisation
  • Smooths out highs and lows
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15
Q

What is the ICD-10 criteria for dependence syndrome?

A

3 of the following, present together within the previous year or constantly over 1 month:

  • A strong desire/sense of compulsion to take the substance
  • Difficulties in controlling substance-taking behaviour in terms of onset, termination, or levels of use
  • Evidence of tolerance
  • A physiological withdrawal state
  • Progressive neglect of alternative pleasures or interests due to substance use
  • Increased amount of time necessary to obtain/take the substance or to recover from its effects
  • Persisting with substance use despite clear evidence of overtly harmful consequences

The patient must feel a desire to take the drug.

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16
Q

What is Disulfram used for?

A

To deter a patient from drinking alcohol

17
Q

Which drugs are used to reduce alcohol craving?

A
  • Acamprosate

- Naltrexone

18
Q

How long does Delirium Tremens take to occur?

A

72 hours, can last up to 5 days

19
Q

What is used for the acute treatment of mania?

A

Olanzapine

20
Q

What is used as maintenance treatment in bipolar disorder?

A

Lithium - mood stabiliser

21
Q

Which medications are contraindicated when taking Lithium?

A

NSAIDs
Ex. Naproxen
Lithium is renally excreted and NSAIDs can reduce renal function