Bipolar Disorder Flashcards
APSs used in Bipolar Disorder
Aripiprazole
Asenapine
Cariprazine
Lumateperone
Lurasidone
Olanzapine
Quietapine
Risperidone
Ziprasidone
BPD Medications for Acute Mixed/Mania
Li,VPA
Carbamezapine
Aripiprazole
Asenapine
Cariprazine
Olanzapine
Quietapine
Risperidone
Ziprasidone
BPD Medications for Maintenance
Lithium
Lamotrigine
Aripiprazole
Olanzapine
Quietapine
Risperidone
Quietapine
BPD Medications for Acute Depression
Cariprazine
Lumateperone
Lurasidone
Olanzapine
Quietapine
What are considered mood stabilizers
Any medications used to treat bipolar disorder
Long-Acting Injectables used for BPD
Aripiprazole
- Maintena
Risperidone
- Consta
True or False. First Gen Antipsychotics have antimanic properties
True
True or False. BZDs have antimanic properties
True
What is the long term adverse effect on Lithium
Kidneys (polydipsia and polyuria)
Thyroid (hypothyroidism)
How is Lithium metabolized?
Not Hepatically
What are the adverse effects of lithium?
Renal function (BUN &Scr)
GI
CNS
Muscle weakness Lethargy
Cardiac Effects
Blood dyscrasia (Clozapine)
What medications must you avoid to avoid lithium toxicity
NSAIDS
ACEi
ARBs
Diuretics
***drugs that affect the renal function
True or False. Lithium is safe to use in nursing mothers
False. It is contraindicated
True or False. Lithium serum concentration levels are related to therapeutic response
False
What enhances neurotoxicity with Lithium use
Calcium Channel Blockers
ECT
What AEDs are approved in BPD?
Lamotrigine
Valproic Acid
Carbamazepine ER (Equetro not Tegretol)
Valproic acid side effects
Weight gain
GI irritation
prolonged bleeding
Alopecia
Valproic acid BBW
Pancreatitis
Hepatotoxicity
Urea disorder
How should you initiate Lamotrigine
Slow Titration
What should you do the dose of lamotrigine when used in combo with Valproic acid
Halve the dose of lamotrigine
What is a serious side effect of Lamotrigine
SJS rash
What are the side effects if Carbamazepine?
Neutropenia
Leukopenia
Hematologic Disease
Agranulocytosis
Asian: HLA-B*1502 (increased risk of SJS/TEN)
True or False. You can use antidepressants exclusively to treat BPD depression
False
What class of Antidepressants and result in switch to mania?
TCAs (&SNRIs)
What is in Lybalvi
Olanzapine
Samidorphan
What is the purpose of samidorphan in olanzapine
Reduce metabolic symptoms of olanzapine
What is Lybalvi indicated for?
Schizophrenia
Bipolar Disorder
What is the contraindication with Lybalvi
Use of opioids
Acute Opioid Withdrawal
