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PHM 701 > Bipolar Disorder > Flashcards

Bipolar Disorder Flashcards

1
Q

APSs used in Bipolar Disorder

A

Aripiprazole
Asenapine
Cariprazine
Lumateperone
Lurasidone
Olanzapine
Quietapine
Risperidone
Ziprasidone

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2
Q

BPD Medications for Acute Mixed/Mania

A

Li,VPA
Carbamezapine
Aripiprazole
Asenapine
Cariprazine
Olanzapine
Quietapine
Risperidone
Ziprasidone

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3
Q

BPD Medications for Maintenance

A

Lithium
Lamotrigine
Aripiprazole
Olanzapine
Quietapine
Risperidone
Quietapine

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4
Q

BPD Medications for Acute Depression

A

Cariprazine
Lumateperone
Lurasidone
Olanzapine
Quietapine

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5
Q

What are considered mood stabilizers

A

Any medications used to treat bipolar disorder

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6
Q

Long-Acting Injectables used for BPD

A

Aripiprazole
- Maintena
Risperidone
- Consta

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7
Q

True or False. First Gen Antipsychotics have antimanic properties

A

True

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8
Q

True or False. BZDs have antimanic properties

A

True

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9
Q

What is the long term adverse effect on Lithium

A

Kidneys (polydipsia and polyuria)
Thyroid (hypothyroidism)

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10
Q

How is Lithium metabolized?

A

Not Hepatically

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11
Q

What are the adverse effects of lithium?

A

Renal function (BUN &Scr)
GI
CNS
Muscle weakness Lethargy
Cardiac Effects
Blood dyscrasia (Clozapine)

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12
Q

What medications must you avoid to avoid lithium toxicity

A

NSAIDS
ACEi
ARBs
Diuretics

***drugs that affect the renal function

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13
Q

True or False. Lithium is safe to use in nursing mothers

A

False. It is contraindicated

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14
Q

True or False. Lithium serum concentration levels are related to therapeutic response

A

False

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15
Q

What enhances neurotoxicity with Lithium use

A

Calcium Channel Blockers
ECT

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16
Q

What AEDs are approved in BPD?

A

Lamotrigine
Valproic Acid
Carbamazepine ER (Equetro not Tegretol)

17
Q

Valproic acid side effects

A

Weight gain
GI irritation
prolonged bleeding
Alopecia

18
Q

Valproic acid BBW

A

Pancreatitis
Hepatotoxicity
Urea disorder

19
Q

How should you initiate Lamotrigine

A

Slow Titration

20
Q

What should you do the dose of lamotrigine when used in combo with Valproic acid

A

Halve the dose of lamotrigine

21
Q

What is a serious side effect of Lamotrigine

A

SJS rash

22
Q

What are the side effects if Carbamazepine?

A

Neutropenia
Leukopenia
Hematologic Disease
Agranulocytosis
Asian: HLA-B*1502 (increased risk of SJS/TEN)

23
Q

True or False. You can use antidepressants exclusively to treat BPD depression

A

False

24
Q

What class of Antidepressants and result in switch to mania?

A

TCAs (&SNRIs)

25
Q

What is in Lybalvi

A

Olanzapine
Samidorphan

26
Q

What is the purpose of samidorphan in olanzapine

A

Reduce metabolic symptoms of olanzapine

27
Q

What is Lybalvi indicated for?

A

Schizophrenia
Bipolar Disorder

28
Q

What is the contraindication with Lybalvi

A

Use of opioids
Acute Opioid Withdrawal

PHM 701 (8 decks)

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