Bipolar Flashcards
Divalproex DDI
- LTG- increase LTG
- CBZ - CBZ toxicity
Potentiates anticoagulant effects with warfarin
Lithium ddi
CBZ
Haloperidol
Ace diuretics NSAIDs sodium depletion- inc li
Sodium supp - decrease li
CBZ Drug interactions
- clozapine bc seizures and agranulocytosis
Lithium adverse effects
Fine tremors Leukocytosis Goiter hypothyroidism Weight gain Polyuria Nephrogenic DI Teratogenic Acne
Lithium toxicity
Coarse tremors Seizures Coma Slurred speech Hypotension
Valproic acid adverse effects
Hair loss Tremors Pancreatitis Hepatotoxicity Teratogenic Thrombocytopenia
CBZ adverse effects
Ataxia confusion Thrombocytopenia Anemia SIADH ( not peeing enough) Elected LFTS Rash- HLAB 1502 - Asian
Quetiapine
Seroquel
Antipsych
Bipolar depression
Bipolar mania
Symbyax
Olanzapine and fluoxetine
Bipolar depression
Ziprasidone
Geodon
Antipsych
Manic
Aripirazole
Abilify
Mania
Asenapine
Saphris
Bipolar mania
Lurasidone
Latuda
Bipolar depression
What two drugs can cause rash
LTG and CBZ
LTG ( lamictal) risk of rash increased by
High dose
Use with Valproic acid
8 Drugs that can cause bipolar
Antidepressants Anticholinergics Cocaine Corticosteroids Decongestants Ephedra L-dopa Sympathomimetics
What assessment tool do u use for bipolar
Young mania rating scale ( YMRS)
- without psychotic features
- with psychotic features
Equetro / tegretol
Carbamazepine
Monitoring for lithium
Renal
Urinary analysis
Long term : renal fxn every 6 to 12 weeks
All common mood stabilizer monitoring conditions
CBC +chem Preg Urinary drug screen EKG >40 Med hx and PE TFTs (thyroid )
All common mood stabilizer monitoring for short term (first two months) and long
Short: serum level every 1 -2 w
Long : serum level every 3-6 months
Monitoring for Valproic acid
LFTs
First two m: CBCs, LFTs monthly
Long term : CBCs, LFTs q6-12 m
Monitoring for CBZ
LFTs
Electrolytes
Renal fxn
First two months : CBC LFTs monthly
Longterm: CBC LFTs q 6-12 months
