Biotin/Vitamin B7 Flashcards

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1
Q

Biotin Structure, Digestion & Absorption
* 2 rings + _____ acid side chain
* Used to be called Vitamin _
* Often bound to protein in foods – freed by
________ & ________ _______
* Absorbed throughout the _____ Intestine

A
  • valeric
  • H
  • intestinal & pancreatic enzymes
  • Small
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2
Q

Biotin Functions
* Coenzyme for multiple carboxylase enzymes
(enzymes that catalyze carboxylation or
decarboxylation reactions)
* Carboxylic acid = -COOH group
Actions of enzymes requiring biotin:
* Form components of _____ _____ (oxaloacetate & acetyl
CoA)
*______ ____ synthesis
* Catabolise odd chain _____ _____
* Catabolise _____

A
  • carboxylase
  • TCA cycle
  • Fatty acid
  • fatty acids
  • leucine
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3
Q

Biotin Deficiency
* Deficiency of biotin alone is _____ EXCEPT
* Is induced when large amounts of
_________ _____ _____ are consumed
* The protein _____ in raw egg white binds
biotin preventing ________
* Thereby impairs lipid and energy
metabolism
- Lethargy, paraesthesia in extremities, hypotonia, depression, hallucinations, red dermatitis. Anorexia, nausea, hair loss, brittle nails, muscle pain
- Fatal if untreated

A
  • rare
  • uncooked egg white
  • avidin, absorption
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4
Q

Biotin Food Sources
* Almost every food contains biotin
* ____,____ & _____ particularly good sources
* Also produced by bacteria in the intestine
(uncertain absorption)

A
  • Nuts, Eggs and Bran
  • bacteria
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5
Q
A
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