biopharmaceutics Flashcards
solutions
tabslets
capsules are examples of
oral formulations
for oral formulations, the absorption half life and bioavailability are dependent on
disintegration and dissolution rates
what factors affect dissolution rate (5)
aqueous solubility drug crystal size excipients (inactive ingredients) -lubricants -starches tablet compression force enteric coatings or controlled release forms
dissolution is slower if the crystal size is
larger
incr in starch ____ dissolution
enhances, speeds up
incr in compression force _____ disintegration time
increases (so takes longer)
device for oral taking of drug: drug contained in core semi permeable membrane on outside permeable to water but not drug soln tiny pore that drug soln can come out of
osmotic pump: GI therapeutic system (GITS)
which order is constant rate
zero order
what order is iv infusion
zero order
large pills are excreted where (cant degrade in GI lumen)
in feces
why is buccal(topical / transfermal) admin advantage over swallowing a pill
avoids first pass effect
fast absorption
if a prodrug is a substrate for CYP2D6. a patient with a deficiency in this enzyme would have what happen to NR clearance of the prodrug
lower NR clearance
administration of a drug tablet w a glass of water instead of meal will do what to absorption half life
decr
meal with oral tablet will do what to absorption
incr absorption half life
carboxylate residues have an affinity for
OATP
