Biomolecular Therapeutics Flashcards
Give some examples of biological therapeutics.
- Vaccines.
- Antibodies (part of the immune system).
- Proteins (cytokines, interleukins, colony-stimulating factors).
- Oligoinucleotides (antisense, gene therapy).
What is angiostatin?
This is an internal fragment of plasminogen approximately 38kDa. It inhibits endothelial cell proliferation.
Describe the tolerability and efficacy of angiostatin.
It is well tolerated by patients and has high efficacy.
Angiostatin is currently in phase 3 clinical trials. Why might it not have much use in the clinic?
It may not have much use in the clinic because of its instability.
What is endostatin?
This is a 20kDa fragment of the c-terminus of collagen XVII. It works by blocking mitogen activated protein kinase (MAPK) in endothelial cell proliferation.
How much more potent than angiostatin is endostatin?
30x.
What does endostatin have potential use in?
Endostatin has potential uses in patients with sarcoma, melanoma, and neuroendocrine tumours.
Why might endostatin not have much use in the clinic?
It may not have much use in the clinic based on its instability.
How does avastin (bevacizumab) work?
Avastin is an anti-VEGF monoclonal antibody which works by sequestering VEGF, preventing receptor activation. Because it is an antibody it binds very tightly and specifically to VEGF.
What is avastin (bevacizumab) used to treat?
It is licensed for the treatment of colorectal, lung, breast (outside the USA), glioblastoma (USA only), kidney, and ovarian cancers.
What are the side effects of avastin (bevacizumab)?
- Heightened bleeding risk.
- Hypertension.
- Exacerbation of CAD.
- Artery diseases.
What is immunotherapy?
These are therapies which exploit one’s own immune system for therapeutic benefit.
Give some examples of immunotherapy.
- Vaccination.
- Therapeutic antibodies/targeting of therapies.
- Activation of the immune system (NK, LAK, CTL, DC).
- Bone marrow transplantation.
What are prophylactic vaccines, with respect to cancer treatment?
Prophylactic vaccines for cancer are often vaccines that build immunity to viral infections which have been linked to certain cancers. There are also vaccines to bacteria that may be linked to cancer.
Give examples of infections which have vaccines against them and that are linked to cancer.
- HPV (viral).
- HepB (viral).
- Helicobacter pylori (bacterial).
Why do viruses have the potential to induce cancer?
Viruses have the potential to induce cancer through their method of reproduction. Because viruses reproduce by inserting their genes into the cellular machinery of a host cell, hijacking this machinery to produce more viruses. This can lead to the induction of oncogenes, leading to cancer.