Biomedical Flashcards
what is inflammation
response of vascularized tissues to infection and damage that brings cells and molecules of hose defense from the circulation to cites where they are needed in order to eliminate offending agents
what 3 main things does inflammation do
- rid the host of the initial cause of injury
- remove necrotic cells and tissues
- initiate the process of tissue repair
what are the cardinal signs of inflammation (medical language)
rubor, calor,tumor, dolor, functio laesa
what are the cardinal signs of inflammation (normal words)
redness, heat, swelling, pain, loss of function
what cells in the blood participate in inflammation
platelets & leukocytes (neutrophils, monocytes, lymphocytes)
what cells in the tissue participate in inflammation
sentinel cells
what are sentinel cells
immune cells that reside in tissues
what are the 3 key features of sentinel cells
- surface/cytosolic receptors invading microbes/ substances released by necrotic tissues
- binging, ingesting and phagocytize microbes and necrotic tissues
- release cytokines and other inflammatory mediators
what are cytokines
signaling molecules secreted by immune cells in response to injury/infection that induce and modulate the immune response (both pro and anti inflammatory)
what are examples of cytokines
interleukins, interferon, TGT-beta, TNF
what is the job of pro-inflammatory cytokines
induce fever, inflammation & tissue destruction in response to injury
what is the job of anti-inflammatory cytokines
suppress actions of pro-inflammatory
what is histamine
molecule released by mast cells that cause vasodilation and increase capillary permeability
what is produced in response to cytokines
prostoglandins and leukotrienes
what is the job of prostaglandins and leukotrienes
contribute to vasodilation, pain, platelet activation
what is hemostasis
immediate response to traumatic injury to prevent blood loss
what is caused by the mediators released by endothelial cells during hemostasis
vasoconstriction, platelet activation, fibrin clot formation
what occur during platelet formation
- platelets adhere to lesion/each other
- cause attraction of other platelets
- initiate coagulation cascade leading to fibrin production
what are the five steps of the inflammatory process
- recognition of injury
- recruitment of white blood cells to area of injury
- removal of injurious agent/damaged tissue
- regulation of response
- resolution
how is injury recognized
sentinel cells in tissue and leukocytes in blood stream
what are the primary roles of recognition in the inflammatory process
ingestion and phagocytosis of microbes and necrotic tissues, cause the release of mediators that trigger recruitment
what mediators trigger recruitment
cytokines, histamines, prostaglandins, bradykinins, leukotrienes
how are cells recruited?
cytokines and inflammatory mediators act on endothelial cells of local blood vessels causing vasodilation, increased vessel permeability and vascular stasis
describe vasodilation during recruitment
triggered by histamine and other mediators released by mast cells; results in increased blood flow accompanied by decreased velocity of flow
describe vessel permeability in recruitment
permeability increased due to endothelial cell retraction; allows for plasma and proteins to lean into tissue causing edema
describe vascular stasis in recruitment
results from increased blood flow and decreased velocity and hemoconcentraion; accounts for redness and warmth of inflamed tissue, facilitates extravasation of leukocytes into tissues
how are leukocytes recruited into tissues
activation, extravasation and chemotaxis
describe activation of leukocyte recruitment
cytokines produced by mast cells and activated by platelets “turn on” leukocytes
describe extravasation of leukocyte recruitment
vascular endothelial cells express surface proteins that “grab” leukocytes causing tehm to roll, adhere and migrate through the endothelium into tissue
describe chemotaxis of leukocyte recruitment
once in the tissue, leukocytes migrate to area of damage
how is damaged tissue removed?
1st wave:neutrophils
2nd wave: macrophages
describe 1st wave removal by neutrophils
microbes and damaged tissues are ingested and destroyed through phagocytosis; neutrophils then quickly die via apoptosis
describe 2nd wave removal by macrophages
phagocytize remaining microbes, necrotic tissue, and dead neutrophils, cleaning up the mess that was made. macrophages also produce anti-inflammatory cytokines that begin to down regulate inflammation
how is inflammation regulated?
once activated, leukocytes have short half lives. anti- inflammatory signals are activated to down regulate inflammation
how does inflammation resolve?
leukocyte activation triggers proliferation and migration of fibroblasts to restore normal tissue function
what can go wrong with the inflammatory response?
too little inflammation, misdirected inflammation, inflammation in response to normally harmless substances, inflammation is excessively prolonged or repetitive
what can result from too little inflammation
infections go unchecked, wounds/tissues don’t heal
what can result from misdirected inflammation
inflammation against body native tissues; autoimmune diseases
what can result from inflammation in response to normally harmless substances
hypersensitivity and allergies
what can result from excessively prolonged or repetitive inflammation
chronic inflammation
what is our role in examination revolving around inflammation
- observe: quality of inflammation & impact on movement/gait
- assess history: how it happened and the pain
- tests and measures: ROM, strength, Gait/movement, edema
what is edema?
excessive fluid in interstitial space
what are the key observations of edema
increased girth of body part, tight, shinny skin, indentation of skin under clothes, weeping/leaking
why is edema a problem?
interferes with normal movement (decreased ROM & control, pain) may indicate a health problem
what health problems could be indicated by inflammation
tissue injury, DVT, heart failure, liver or kidney disease
what are the 3 types of edema
inflammatory, non-inflammatory, effusion
what characterizes inflammatory edema
red, hot, painful; typically due to trauma, swelling or inflammatory reaction
what characterizes non-inflammatory edema
pitting: press into skin and pits form. has a variety of causes
what characterizes effusion
excess fluid enclosed in a space.
joint effusion = in capsule
pleural effusion = in pleural space
how can you describe edema
location, duration, inflammatory vs pitting, amount (girth/volume)
what is a typical prognosis of inflammation
1-2 weeks; if no change in signs/symptoms consider other factors such as repeated injury or other sources if inflammation
what is the goal in intervention for inflammation
to manage and promote healing
what is the main principle for inflammation intervention
POLICE Protection Optimal Loading Ice Compression Elevation
what are the functional regions of a neuron
input, integrative, conductive, output
what is the major difference between a motor neuron and a sensory neuron in the PNS
sensory neurons have cell posies that lie just outside the spinal cord while motor neurons have sell bodies in the spinal cord
what is the job of the Endoplasmic reticulum
synthesis of lipids and vesicles
what is the job of the lysosome
digests glycogen to glucose; part of the axoplasmic transport system
what are the functions of an axon
- transmission of information: propagation of AP
2. transportation of metabolically important materials to and from the soma to the axonal end
Describe myelinated axons in the PNS
myelinated by Schwann cells that enveloping them with up to 300 concentric layers forming myelin sheath
how do neurons transmit information within the neuron
action potential
how do neurons transmit information between neurons
synapse
what are the cellular mechanisms for neural transmission of information
resting membrane potential, post synaptic potential, action potential
what are the synaptic mechanisms for neural transmission of information
convergence and divergence
what are the behavioral mechanisms for neural transmission of information
feed-forward and feedback
what is the importance of resting membrane potential
regulates activation so that neurons do not randomly fire
what is the role of the cell membrane in resting membrane potential
creates a physical barrier keeping ion charges separate due to selective permeability
what are the two types of forces that guide movement of ions
electrostatic force and diffusion force
what is electrostatic force
like charges repel eachother
what is diffusion force
ions tend to move from higher concentration to low concentration
what are the types of mechanisms for ion transport
ion channels and active mechanisms
what are the types of ion channels
ligand gated - had a receptor that must be bound to open
mechanically gated - mechanical stress applied at level of channel open them
voltage gated - opens & closes at specific voltage across a membrane
leakage - randomly open for shits and gigs
what is the active mechanism for ion transport
Sodium potassium pump! requires ATP, transports 3 Na+ out and 2 K+ in against diffusion gradient