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in service ASPS > biomaterials and implants > Flashcards

biomaterials and implants Flashcards

1
Q

what are the components of integra

A

bilayer wound matrix or single layer w/o silicone
semi-permeable silicone (mimics epidermis)
cross linked bovine tendon collagen GAGS (dermal)

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2
Q

what are the components of apligraf

A

living bilayer skin sub
dermal = bovine type 1 collagen + human fibroblasts
epidermis = human keratinocytes
cells from neonatal foreskin

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3
Q

Bone subs

A

demineralized bone matrix
coral
hydroxyapatite
calcium sulfate
calcium phosphate/tricalcium phosphate

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4
Q

what are the basis of alloderm, flex HD, allomax?

A

human

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5
Q

what are is the source for strattice, permacol?

A

porcine

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6
Q

what is the source of veritas, surgimend?

A

bovine

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7
Q

what side of alloderm is placed towards vasculature?

A

shiny

must be used within 4hrs of rehydration

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8
Q

what revascularizes faster cancellous bone or cortical bone?

A

cancellous bone

cortical bone is structural

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9
Q

what is endochondral ossification?

A

bone formed from hyaline cartilage model that becomes partially ossified
- retains cartilaginous portion as articular cartilage and epiphyseal growth plate

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10
Q

what is osteoconduction?

A

cortical bone graft functions as nonviable scaffold for gradual ingrowth of blood vessels nd osteoprogenitor cells from recipient site

gradual resorption and deposition of new bone (creeping sub)

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11
Q

what is osteoinduction

A

transformation of local host mesenchymal cells into bone forming cells in prescence of inductive stimulus (BMP)

regulated by insoluble polypeptide morphogens BMP

requires demineralization prior to implantation

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12
Q

how is cartilage warping/shaping minimized?

A

symmetric carving

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13
Q

what collagen substitute requires skin testing 4 weeks prior to use?

A

zyderm/zyplast
bovine

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14
Q

what is the source of collagen substitute cosmoderm/cosmoplast

A

human

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15
Q

what is the source of collagen substitute evolence?

A

porcine

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16
Q

what are the components of hyluronic acid

A

d-glucuronic acid and N-acetyl-glucosamine

repeating disaccharide

restylane/perlane
juvederm
belotero
prevelle silk
hydrelle
captique
hylaform

17
Q

what is radiesse

A

calcium hydroxylapatite 30% in cellulose gel

18
Q

what is the common component in resorbable sutures and plates

A

polylactic acid

degraded by hydrolysis into lactate
lasts for 2-5yrs

19
Q

what is sculptra made of

A

poly-L-lactic acid

20
Q

what is polymethylmethacrylate used in?

A

bone cement

stimulates host collagen deposition

21
Q

what is artefill made of

A

bovine collagen and PMMA microscpheres

skin test required for anything bovine collagen

PMMA is permanent

22
Q

what is the estimated resorption of fat at 12 months

A

50%

70% at 3 months

23
Q

what is autologen?

A

autologous skin harvest

24
Q

what is isolagen

A

cultured punch biopsies

25
Q

what is dermalogen

A

cadaveric tissue

26
Q

what is fascian

A

preserved particulate fascia (cadaveric)

27
Q

what is the 10 yr reoperation risk of saline implants?

A

25%

28
Q

when is the silicone layer of integra removed?

A

21 days (minimum may be better to wait full 4 weeks)

after the GAG layer is fully revascularized

29
Q

what increases the longevity of saline implants?

A

as volume increases palpable and visible wrinkling decreases

underfilled implants have also shown to wrinkle more leading to shorter lifespan because of the stress induced by wrinkling

30
Q

what characteristic of hyaluronic dermal fillers is responsible for prolonging results

A

cross-linking

31
Q

does cartilage graft vs bone graft have less or greater resorption

A

cartilage have less resorption and volume loss

1/100-1/500 metabolic rate compared with other human tissues
low gylcolytic activity and consumption because of its small cell population and relative isolate by the cartilage matric

32
Q

what is the advantage of using integra with STSG rather than just skin graft alone

A

reliability of placement technique, pliability, and final cosmetic appearance

allows for thinner graft so less risk of overall scarring, infection and pigmentation changes
less wound contraction
longer healing time due to it being a staged procedure

33
Q

does hydroxyapatite bone cement allow for peripheral ingrowth of bone

A

yes it is osteoconductive

no risk of endothermic rxn (seen with methylmethacrylate cement)
does not lose contour over time

in service ASPS (7 decks)

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