Biology - Transport in Humans Flashcards

1
Q

What are the functions of blood?

A
  1. Transport oxygen and other nutrients around
    the body
  2. Protective function against disease-causing
    organisms
  3. Distribution of heat in the body
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2
Q

What are the components of blood?

A

Plasma (55%), red blood cells (erythrocyte), white blood cells (leucocyte), platelets

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3
Q

What is plasma and its functions?

A
  • yellowish liquid
  • contains mainly water and substances such as glucose,
    salts, proteins, amino acids, fats, vitamins, hormones and urea
  • contains red and white blood cells
  • carries blood cells and nutrients (from small intestines) to rest of body, as well as excretory products (from organs) and hormones (from endocrine glands)
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4
Q

What are red blood cells and their functions?

A
  • circular, biconcave in shape; no nucleus; containing hemoglobin; flexible
  • transport oxygen from lungs to rest of body
  • biconcave shape increases SA:V –> increases rate of absorption and release of oxygen
  • no nucleus –> more space for storage of hemoglobin (combines reversibly with oxygen)
  • 90-120 days lifespan
  • destroyed in spleen –> Hemoglobin released, brought to the liver and broken down
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5
Q

What are white blood cells and their functions?

A
  • irregular in shape, contains a nucleus
  • can change its shape and squeeze into thin blood capillaries
  • produced in bone marrow, lifespan of a few days
  • two main types: lymphocytes and phagocytes
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6
Q

What are lymphocytes and their functions?

A
  • rounded, large round nucleus, small amount of non-granular cytoplasm
  • produce antibodies that recognise and destroy foreign particles and disease-causing bacteria and viruses
  • clumps together bacteria for phagocytosis and neutralises the toxins produced by them
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7
Q

What are phagocytes and their functions?

A
  • lobed nucleus and granular cytoplasm
  • performs phagocytosis where it engulfs (ingests and digests) and destroys foreign particles such as bacteria
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8
Q

What are platelets and their functions?

A
  • not true cells, just fragments of them
  • produced in the bone marrow.
  • lifespan of about 6 days.
  • blood clotting mechanism; converts fibrinogen to fibrin threads which entangle with red blood cells to form blood clot that seals wound
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9
Q

What are the parts of the circulatory system?

A

heart, blood vessels, arteries, arterioles, blood capillaries, venules, veins

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10
Q

What are arteries and their characteristics?

A
  • carry oxygenated (except pulmonary artery) blood away from heart at high pressure
  • wall has a thick layer of smooth muscle, muscle contractions to maintain blood pressure
  • wall has a thick layer of connective tissue (collagen and elastic fibers) to prevent bursting
  • wall has large amount of elastic fibers, blood flow is not continuous, occurs in pulses with the contractions of the heart
  • elastic fibers allow the artery to stretch (for large amounts of blood), provides elastic recoil helping to push the blood
  • elastic layer is thicker nearer the heart
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11
Q

What are capillaries and their characteristics?

A

Arteries (branch into) –> arterioles –> capillaries found between cells of almost all tissues
- only region where the exchange of materials occurs between blood and the tissue fluid surrounding the cells
- single layer of flattened cells as wall (endothelium) with numerous pores for quick diffusion between lumen and surrounding tissue fluid
- blood cells, most plasma proteins are too large –> remain in capillary
- capillary network of numerous branches for larger surface area, which lowers blood pressure
- slower blood flow for more time for exchange of materials
Capillaries (merge to) –> venules –> veins

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12
Q

What are veins and their characteristics?

A
  • carry deoxygenated (except pulmonary veins) blood at low pressure towards the heart
  • wall has thin layer of smooth muscle, few elastic fibers, thinness allows vessel to be squeezed during muscle contraction
  • many veins situated between large skeletal muscles
  • lumen is much wider relative to the overall diameter of the vein, accommodate large volume
  • valves present to prevent backflow, folds of the inner walls, shaped like half-moons, called semi-lunar valves
  • wider lumen compared to overall diameter
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13
Q

What are the types of circulation?

A

double circulation: blood passes through the heart twice in every cycle of flow through the body in mammals and consists of:
pulmonary circulation:
- flow of blood between heart and lungs
- pulmonary arteries carry deoxygenated blood from heart to lungs
- pulmonary veins return oxygenated blood to heart
systemic circulation:
- flow between the heart and other parts of body
- oxygenated blood transported by arteries from left side of heart to rest of body (except lungs)
- veins carry blood from body back to right side of heart

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14
Q

What are the parts of the heart?

A

4 chambers - Right and left atria, right and left ventricle
- Pulmonary artery
- Pulmonary veins
- Aortic valve
- Bicuspid valve
- Septum
- Superior vena cava
- Pulmonary valve
- Tricuspid valve
- Inferior vena cava

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15
Q

What is the structure of the atria?

A
  • Two upper chambers
  • Thinner walls than ventricles since they only force blood into the ventricles –> does not require high pressure
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16
Q

What is the structure of the ventricles?

A
  • Two lower chambers
  • Larger in size than the atria, thicker walls
  • Left ventricle has a thicker muscular wall than the right as it has to pump blood all around the body –> requires high pressure, while the right only pumps blood to the lungs which are close to the heart
17
Q

What is the role of the median septum?

A
  • Muscular wall running down the middle, separating left and right sides
  • Prevents the mixing of deoxygenated blood in the right side of the heart with the oxygenated blood in the left side of the heart, which would reduce the amount of oxygen carried to the cells in the tissues.
18
Q

What is the role of valves?

A

Flow of blood is controlled by the opening and closing of valves. (close when pressure drops)
- Tricuspid valve (atrioventricular valve) prevents backflow of blood from the right ventricle to the right atrium
- Bicuspid valve (atrioventricular valve) prevents backflow of blood from left ventricle to the left atrium
- Aortic valve (semi-lunar valve in the aorta) prevents backflow of blood from aorta to the left ventricle.
- Pulmonary valve (semi-lunar valve in the pulmonary artery) prevents backflow of blood from pulmonary artery to the right ventricle.

19
Q

What is the cardiac cycle?

A

Takes place in one heartbeat.
1. Atrial muscles contract, forcing blood into the ventricles
2. After a short pause, ventricular muscles contract –> pressure rises in ventricle, causes atrioventricular valves to close - ‘lub’ sound produced. semi-lunar valves open, blood flows from ventricles to pulmonary artery and aorta respectfully
3. Ventricular muscles contract –> atrial muscles relax. Right atrium receives blood from venae cavae, left receives from pulmonary veins
4. Ventricular muscles relax, pressure drops, semi-lunar valve closes –> ‘dub’ sound produced. atrioventricular valves open, blood flows from atria to ventricles, cycle repeats

20
Q

What are the phases of the cardiac cycle?

A

systole: when ventricular or atrial muscles contract
diastole: ventricular or atrial muscles relax
(72 beats/min on average for adults)

21
Q

What are the pressure changes in the cardiac cycle?

A
  • During systole, pressure is at max for ventricles and atria at peak of contraction, decreases during diastole
  • Pressure differences during alternating diastole and systole of ventricles and atria (valves open and close reacting to pressure changes, etc)
22
Q

What is the order of pressure changes in the cardiac cycle?

A
  1. Slight increase in ventricular pressure: left atrium contracts, forced blood in relaxed ventricles
  2. Pressure increases: AV valves close
  3. Left ventricle pressure higher than in aorta: Semi-lunar valve in aorta opens
  4. Ventricle begins to relax, aortic valve closes
  5. Pressure in ventricle decreases: relaxes
  6. Pressure lower than in atrium: AV valves open
  7. Pressure in ventricle increases, blood enters from atrium
23
Q

What is coronary heart disease?

A

Blockage of coronary arteries (branched from aorta, carry blood to heart muscles), reducing blood supply to heart muscles –> heart attack where blood flow may be completely blocked, the part does not receive sufficient oxygen and nutrients –> death
Causes: Fatty substances (cholesterol, saturated fats) form deposits on inner surface of of coronary arteries (atherosclerosis) Narrow lumen, increases blood pressure, risk of blood clot formation.
Smoking, unhealthy diet, sedentary lifestyle. Can avoid smoking, eat healthily, exercise regularly