Biology Of Aging

Question 1

What are the two major groups of aging?
Can you give examples of the two (5) (3)?

Answer 1

Damage theories: environmental assaults over persons lifespan causing aging eg UV exposure
Wear and tear theory, rate of living theory, cross linking theory, free radical theory, somatic DNA damage theory

Program theories: aging follows a biological timetable
Programmed longetivity, endocrine theory, immunological theory

Question 2

What are the nine hallmarks of biological aging?

Answer 2

Genome instability
Telomere attrition
Epigenetic changes
Mitochondrial dysfunction
De-regulated nutrient sensing
Stem cell exhaustion
Cell senescence
Altered cell signalling
Impaired proteostasis