BIOLOGY LECTURE 2 Flashcards
Immunity
condition where the body is protected from various threats, like pathogens, toxins, and cancer cells
Antigen
any molecule that stimulates an immune response; can be a bacterium, a protein on the surface of a virus, etc.
How many types of immunity is there?
two
What are the two types of immunity?
innate immunity and adaptive immunity
Innate immunity
mechanisms are fully functional WITHOUT previous exposure to antigens (takes a few hours to occur)
Adaptive immunity
initiated and amplified after specific recognition of antigens (takes days to occur)
Lymphoid organs
contain large numbers of lymphocytes; primary lymphoid organs and secondary lymphoid organs
Primary lymphoid organs
red bone marrow and thymus; lymphocytes develop and mature here
Secondary lymphoid organs
lymph nodes and spleen; lymphocytes become active here, as they are exposed to foreign molecules/cells
Lymphocyte
a type of white blood cells (WBC); consist of B-cells and T-cells
B-cells
produce antibodies to attack foreign invaders; made AND mature in bone marrow
T-cells
direct fighters of foreign invaders and help to activate other parts of your immune system; made in bone marrow BUT mature in thymus
Red bone marrow
primary lymphoid organ; contains stem cells that can produce RBC and some WBC; ALL lymphocytes begin development here
Stem cells
a kind of cell that is capable of becoming any kind of specialized cell in the body (e.g., can become a RBC, a macrophage, etc.)
Thymus
primary lymphoid organ; located in the thoracic cavity between your sternum and the trachea; grows largest around puberty, shrinks as we age; filled with T-cells, which MATURE here
Where does the “T” in “T-cells” come from?
thymus
What percent of T-cells actually leave the thymus to fight foreign invaders?
5%
What are the two possibilities of maturing T-cells in the thymus?
- T-cells respond to your own cells
- T-cells respond only to foreign cells
What happens when T-cells respond to your own cells?
they die via apoptosis
What happens when T-cells respond only to foreign cells?
they survive and leave the thymus