Biology Exam 1: Evolution Flashcards
Lectures 1-4
Cardia bifida example for why knowledge of evolution is important in medicine
Humans are bilateral symmetric organisms (mirrored development on both sides of the body). The hearth results from the fusion of two proto-hearts thus explaining WHY cardia bifida exists.
Hernia example for why knowledge of evolution is important
Hernias are 25x more common in men than women because the descent of the testes through the abdominal wall causing an area of weakness, making men susceptible to hernias
What is the unifying theme in biology?
evolution
Untrained assumption: disease causing organisms will change over time to become more benign. Reality:
disease causing organisms are constantly evolving to become more fit, thus becoming more dangerous to their hosts
Untrained assumption: Humans will eventually evolve to be resistant to disease causing organisms
Disease causing organisms can evolve much faster than humans because of their low generation time, meaning that over time humans will become less resistant due to more dangerous bacteria
When did antibiotics first start losing their effectiveness?
1950’s
Factors that lead to antibiotic resistance: (5)
- over prescribing
- inaccurate prescribing
- early discontinuation of use
- high density low sanitary living conditions
- extreme overuse in livestock industry
Give two examples of Evolutionary anatomy
- Wisdom teeth impaction because of the shrinking of human jaws
- the complexity of the cranial nerves because as the muscles and bones of the skull shifted, the nerves attached to these structures shifted as well (cranial nerve XI is associated with shoulder shrugging because your collarbone was part of your gill covering millions of years ago
What organism is used as a model for Alzheimer’s research? What portion of our genome is identical to this organism?
yeast. 2/3
Assumption of population biology: biological populations will evolve to restrain their own reproduction so as to benefit the species.
Reality: every organism for him/herself: the evolutionary goal is to pass on one’s genes
With what two scientists and when did our modern understanding of evolution begin?
Buffon and his protege Lamarck in the 1700’s
Why were the groundbreaking ideas of Buffon and Lamarck quickly rejected during their time and by whom were they rejected best?
Couvier:
- tinkering with a complex and fantastic machine suck as the human hand can only do more harm than good
- Fossils=the aftermath of the biblical flood. (Couvier was the first person to understand extinction in Western culture)
- Egyptian cat v. modern cat (~5000 years): found no change
- People accepted biblical creation
Who created a date of creation based on theology and what was it? Who changes this idea?
James Usher: Oct 23, 4004 BC at 9:00 am.
James Hutton
Hadrian’s wall
Hutton’s wall had been there for 1500 years and was relatively perfect. If 1500 years didn’t change a wall, how long would it take to carve a canyon? Thus he realized the earth had to be incredibly old.
Hutton’s unconformity
many layers, some vertical and some horizontal. Layers showed how old earth must be and the different orientations ____________.
Darwin was not the first to hypothesize evolution. What did he do?
He came up with the mechanism for evolutionary change: natural selection
In what year did Darwin publish the Origin of Species?
1859
Law of fossil succession (+example)
If two species are evolutionarily related, we should be able to find a pattern where the extant (living) and extinct (dead) forms live. Example: Glyptodont and armadillo
Two v important questions Darwin had to be able to answer if people were going to believe him
- HOW do species change?
2. WHY do species change?
________ keeps population size in check
competition
What happens to species that allows them to better compete for limited resources?
They change (WHY?)
The first evolutionist who confidently and publicly stated his ideas about the processes leading to biological change
Lamarck, Buffon’s protege. Buffon was one of the first scientists to postulate that life was not fixed.
When did the idea of evolution first begin?
1700’s
Who was responsible for the dismantling of early evolution?
Couvier. He was the first comparative anatomist and the fist person to dismantle evolution with something other than the Bible
James Usher
Put a date on creation. He used the bible, started at Christ, and moved backwards to get October 23, 4004 BC at 9am
James Hutton
Hadrian’s wall and hutton’s unconformity: Hutton first states that the earth is way older than we thought it was
Catastrophism:
How scientists married the Bible with logic and an old Earth.
Charles Lyell
Picks up on age of the earth work where Hutton left off. Writes Principals of Geology, the first geology textbook and a book that would be given to Darwin right before he boarded the HMS Beagle. Lyell was the man to refute catastrophism in favor of uniformitarianism: the earth doesn’t just look old, it IS old
Charles Darwin
Darwin did not start as an evo. thinker or much of a thinker at all but after he returns from his trip on the HMS Beagle he is obsessed. Darwin was not the first person to hypothesize evolution but he WAS the first to come up with a mechanism for it.
Darwin’s three ideas on evolution
- 2.
3.
Thomas Mathus
Political economist of the late 1700’s- warned about uncontrolled population growth. Darwin picks up his book and has an Ah-hah moment (?)
What did pre-darwinian evolutionary theorists stress?
Perfection, hierarchy, and increasing complexity
Darwinian evolution showed that evolution is about:
competition for limited resources and reproduction. He showed that evolution has no direction and that there is no real hierarchy of beings (no higher/lower)
The superior competitors are always more/less complex?
Either could have the advantage. Example: cave fish evolving to lack eyes or surface pigment
Darwin’s main problem in his theory of evolution published in “On The Origin of Species” in 1859 was that… (2)
- He didn’t know HOW traits were passed down from parent to child (this information was found with Mendel in Darwin’s lifetime but no one actually read it)
- How do you get new traits to arise?
When was DNA discovered?
1953
Though Darwin’s theory on evolution was published in ______, the theory remained unaccepted and highly controversial until ______ in the ______ community
1859
1950’s
Academic
What are 5 pieces of evidence in favor of evolution?
- Transitional Forms
- Vestigial Traits
- Homology in Development
- DNA Analysis
- Chromosomal Analysis
Radiometric dating
a technique used to date materials such as rocks or carbon, in which trace radioactive impurities were selectively incorporated when they were formed. The method compares the abundance of a naturally occurring radioactive isotope within the material to the abundance of its decay products, which form at a known constant rate of decay
Example of transitional forms
Lucy
Example of vestigial traits
what is left of limbs on a snake butt, whale pelvis
Example of homogeny in development (3)
- embryos of vertebrates showing extremely similar structures during development
- The circulatory system of a human at 29 days of development is almost the same as that of a fish.
- forelimbs of mammals (one bone, two bones, wrist bones, fingers)
Examples of DNA Analysis
Percent similarities:
- Chimp 99%
- Gorilla 98%
- Mouse 93%
Examples of chromosomal evidence
Chromosome 23 in humans which appears to be a merge of the 2 chromosomes that make up chromosome 23 in chimps
Name the 5 tenants of modern evolutionary recursion
- New DNA mutations occur in every generation
- These mutations produce individuals that are genetically and physically different from each other (ie population variation)
- Individuals within a population compete with each other for limited resources
- The outcome of competition is non-random: these traits make some individuals more successful than others and
- These successfully competing organisms are more likely to contribute more genes to the next generation than unsuccessful individuals are.
If the 5 tenants of modern evolutionary recursion are true, what must also be true?
The gene pool will change over time- evolution is genetic change over time
Intelligent Design
William Paley: pocket watch on an island: Humans and animals and plants are too complex to have been made naturally, we need an “intelligent designer” AKA God. Even the pope rejects this shit. (PPJII)
Father John Zahm
One of the first Catholic leaders to stand up for evolution
Theory v Hypothesis
When people use the word theory, they typically mean hypothesis or guess.
Hypothesis: a suggested explanation for an observable phenomenon.
Theory: is a tested, well-substantiated, unifying explanation for a set of verified, proven factors.
Individuals (do/do not) evolve.
do not. populations evolve but selection acts on the individual
Artificial selection and what we can learn from examples of artificial selection (2)
accelerates evolution
Examples: wild mustard plant and bristle number on drosophila
1. Natural populations have significant heritable variety
2. Heritable variety is easily acted in by a selective agent to cause evolutionary change
Natural selection
differential survival and reproduction of individuals in a population based on heritable (genetic) variation. Natural selection is the mechanism by which evolution occurs.
Evolution
change in genetic frequencies (composition) of a population
Hardy-Weinberg Equilibrium
Why is it useful?
What does it assume?
p2+2pq+q2=1 with 1=100% frequency
p2=AA // 2pq=Aa // q2=aa
The utility of the HW equation is that it teaches us the various forces that causes changes in gene frequencies
HW assumes no mutations.
What conditions must be met in order for population gene frequencies to stay constant?
- Mating is random (does not always occur in nature)
- Population size in large
- No flow of genes in or out of the population
- No new mutations occuring
- No natural selection
genetic drift
When population size is small, gene frequencies can change randomly. This can cause the the loss of advantageous alleles or perpetuation of deleterious alleles.
Founder effect
when a large population has a section isolated and a new population is started from just those few individuals
Population bottleneck
a population in reduced in size
All new heritable features of organisms ultimately arise from _________.
mutation