Biologics Review Flashcards by Andrew Cobert

Infliximab target

TNF

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Rituximab target

CD20

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Ixekizumab target

IL-17A

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Natalizumab

mucosal and endothelial adhesion molecules

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Tildrakizumab-asmn

p-19 subunit of IL-23

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Toclizumab

IL-6 receptor

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Vedolizumab

mucosal adhesion molecule

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Adalimumab

TNF

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Brodalumab

IL-17RA

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Guselkumab

p-19 subunit of IL-23

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Sarilumab

IL-6 receptor

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Golimumab

TNF

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Secukinumab

IL-17A

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Ustekinumab

p40 subunit of IL-12 and IL-23

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Certolizumab

TNF

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Abatacept

CD80 and CD86

Etanercept

TNF

Guselkumab binds to the p__ subunit of IL-__; inhibiting its interaction with the IL-__ receptor, thus inhibiting the release of proinflammatory cytokines and chemokines.

19, 23, 23

What are the 3 types of recombinant antibody fragments?

Fragment of antigen binding (Fab), Single chain variable fragments (ScFv), 3rd generation (3G molecules)

Certolizumab is an example of what?

Fab