biologics lyophilized power Flashcards
1
Q
advantages of lyophilized powders
A
reduced rates of chemical and physical degration
improved drug stability and longer shelf-life
refigerated stroge is not usually needed
can use lyophilized formulations in pre-filled syringes, pens, auto-innjectors
2
Q
disadvantages of lyophilized powders
A
must be reconstituted prior to injection; less convinient than solutions
more expensive and time consuming to manufacture
3
Q
what is lyophilization
A
aka freeze drying
removes water by sublimation
occurs at low temp and low pressure
gentler than othe rmothods of removing water better for fragile drugs
4
Q
how does lyophilization work?
A
