Biologics

Question 1

Traditional drugs

Answer 1

• synthetic organic compounds
• defined structure, physical and chemical characteristics
• small MW
• linear dose response
• biotransformed
• NOT species specific

Question 2

Biologics

Answer 2

• protein, carb, nucleic acid structures
• extracted from living organism
• large MW
• heat and shear sensitive
• non linear dose response
• species dependent

Question 3

u

Answer 3

human

Question 4

o

Answer 4

mouse

Question 5

xi

Answer 5

chimeric

Question 6

zu

Answer 6

humanized

Question 7

Biologics elimination

Answer 7

RES

antigen specific target mediated disposition

Question 8

Common side effects of biologics

Answer 8

• infusion site reactions
• allergic reactions
• flu like symptoms
• N/D
• decreased blood cell counts

Question 9

Etanercept

Answer 9

• anti-TNF
• TNF receptor
• shortest DOA
• RA, psoriasis, psoriatic arthritis

Question 10

Side effects etanercept

Answer 10

Ha, allergic reaction, rash, URI

Question 11

BBW anti TNF drugs

Answer 11

for serious infections, malignancies

Question 12

Infliximab

Answer 12

• anti-TNF
• partially humanized
• Crohn’s disease, ulcerative colitis

Question 13

Infliximab side effects

Answer 13

CV effects

Question 14

adalimumab

Answer 14

• anti-TNF

- fully humanized

Question 15

Adalimumab side effects

Answer 15

• develop antibodies against drug

- cause demyelination

Question 16

CI adalimumab

Answer 16

patients with demyelinating diseases (MS)

Question 17

bevacizumab

Answer 17

• angiogenesis inhibitor
• stops formation of new blood vessels, inhibit VEGF
• treat cancers, eye diseases

Question 18

BBW bevacizumab

Answer 18

hemorrhage, delayed wound healing and GI perforations

Question 19

Abciximab

Answer 19

• GPIIb/IIIa antagonist
• prevent platelet aggregation
• percutaneous coronary intervention

Question 20

Side effects abciximab

Answer 20

• bleeding
• thrombocytopenia
• allergy

Question 21

Omalizumab

Answer 21

• IgE inhibitor

- moderate to severe asthma

Question 22

BBW omalizumab

Answer 22

for anaphylaxis presenting as bronchospasm

Question 23

side effects omalizumab

Answer 23

• injection site reactions

- CV events

Question 24

Pembrolizumab

Answer 24

• Block PD1
• humanized
• cancers

Question 25

Side effects pembrolizumab

Answer 25

• rash (SJS)
• fatigue
• T1D

Question 26

Nivolumab

Answer 26

• block PD1
• fully human
• metastatic cancer

Question 27

Side effects of nivolumab

Answer 27

• Rash (SJS)
• adrenal insufficiency
• T1D
• GI toxicity: diarrhea, colitis

Question 28

What can nivolumab be used with?

Answer 28

ipilimumab (synergistic)

- metastatic melanoma

Question 29

Atezolizumab

Answer 29

• block PD-L1
• humanized
• metastatic lung cancer
• metastatic urothelial carcinoma

Question 30

Side effects of anti PD-L1 drugs

Answer 30

• adrenal insufficiency
• CV toxicity
• T1D
• infection risks

Question 31

avelumab

Answer 31

• block PD-L1
• fully human
• Merkel cell carcinoma
• advanced metastatic urothelial carcinoma

Question 32

durvalumab

Answer 32

• block PD-L1
• fully human
• metastatic urothelial carcinoma

Question 33

Ipilimumab

Answer 33

• CTLA-4 inhibitor
• fully human
• metastatic and non-metastatic melanoma

Question 34

BBW ipilimumab

Answer 34

• immune mediated reactions (months to weeks after treatment stops)

Question 35

CTLA-4 inhibitor drugs

Answer 35

ipilimumab

Question 36

PD-L1 inhibitor drugs

Answer 36

• atezolizumab
• avelumab
• durvalumab

Question 37

PD-1 inhibitor drugs

Answer 37

• pembrolizumab

- nivolumab

Question 38

IgE inhibitor drugs

Answer 38

• omalizumab

Question 39

Anti platelet drugs

Answer 39

• abciximab

Question 40

Malignancies drugs

Answer 40

• bevacizumab

Question 41

Anti-TNF drugs

Answer 41

• etanercept
• infliximab
• adalimumab