Biological Treatment SZ - Drug Treatment

Question 1

One Biological Treatment SZ

Answer 1

Drug Treatments
If SZ caused by an excess or a deficiency of a certain neurochemical, then medication can be used to correct this imbalance.

Question 2

BIO T - First Generation Antipsychotics SZ

Answer 2

Chlorpromazine:
- First antipsychotic medication.
- Dopamine antagonist, reducing positive symptoms by blocking postsynaptic dopamine receptors without activating them.
- Most effective ones bind to D2 receptors.
- 40% gain no relief and still experience - symptoms

Question 3

FGA side effects

Answer 3

Side effects are stiff/slow writhing movements of body that you can’t control. Leading to poor compliance and subsequent relapse.

Question 4

Second Generations Antipsychotics SZ

Answer 4

Clozapine:
- Blocks dopamine in the same way as FGA but acts on serotonin and glutamate receptors.
- Reduces both + and - symptoms
Provides relief for up to 60% of people.

Question 5

SGA Side effects

Answer 5

• Side effect is a blood condition called agranulocytosis
• Regular blood tests to make sure they are healthy.

Question 6

Supporting Study for Drug Treatments

Answer 6

Ying Jiao Zhao et al 2016:
- Meta analysis of 18 antipsychotics using data from 56 randomised control trials with 10,000+ people.

• Found that 17 of the antipsychotics had significantly lower relapse rates than placebo.
• Drug treatments can be helpful to allow SZ people to avoid emotional and financial costs of hospital treatments.

Question 7

Competing the supporting study for DT

Answer 7

Krishna Patel et al:
- 20% of people with SZ show negligible improvement after multiple FGA trials.

• 45% experience only partial or inadequate improvement and unacceptable side effects

Question 8

Application of Drug Treatments SZ

Answer 8

De-intstitutionalisation:

Antipsychotic drugs meant that in the 1950’s people had a chance of staying in the