biological therapies Flashcards
what are the two drugs that are used to help treat schizophrenia
- typical
- atypical
whats an example of a typical drug
chlorapromazine
what were typical drugs used for
to calm patients down before surgery
when were typical drugs developed?
1950s
what does chlorpromazine do?
- blocks dopamine ativity by sitting on D2 receptor neurones
- this prevents the impulse from crossing the synapse
what is an example of an atypical drug?
clozapine
what do atypical drugs do?
reduces dopamne activity within a patient`
when were atypical drugs invented?
1970s
theyre more modern thus more expensive
how do atypical drugs work?
- they target the D1/D4 receptors and dissacociate quicker allowing a briefer block
- some research suggests thst thye target seratonin receptors
typical drugs-strength
explain the work of sampath on typical drugs 1992
- swapped out clorpromazine for a placebo drug in half of his sample
- 75% of the placebo grp relapsed a year later compared to 33% of the patiets who recieved the drug
- this supports the effectiveness of drugs as is shows they can help reduce symptoms
- the study is correlational so cannot infer causality
atypical drugs - strength
explain the work of meltzer 1999 within atypical drugs
- he found that 1/3 of patients that didnt show improvement with typical meds responded to
- this work is supported by Vorganti 1999 who found that atypical drugs benefit 85% of patients compared to the 65% that typical drugs benefitted
- supports atypical drugs as it shows they help reduce S symptoms
atypical/typical durgs-strength
what are strengths of both drugs?
- cheap compared to treatements such as CBT-good value on public health systems NHS
- aren’t disruptive to patients lives’-not like therapy
- a pragnatic and cost effective way for sufferers
typical/atypical weakness
why are side effects a weakness?
- some patients on antipsychotics develop tardive dyskinsea- an uncontrollable facil tic disease
- even after stopping the drugs the tics carried on- it can also become fatal
- side effects are less severe when a smaller dose is taken
- side effects are a weakness as they reduce the likelihood of a patients taking the drug