Biological Systems Considered From The Dimensions Of Time - Lecture 6 Flashcards
1
Q
Trajectory
A
- Growth, development and aging
- Years and Decades
- Long dimensions of time
2
Q
Rythms
A
- Maintenance and Repair
- Days, weeks or moths
- Short dimensions of time
3
Q
Homeostasis or Balance
A
- Maintenance of steady state
- Seconds, minutes, hours
- Shorter dimensions of time
4
Q
Energy and Information Flow
A
- Actions potentials, enzymatic reactions
- Milliseconds and microseconds
- Shortest dimensions of time
5
Q
Maximizing Healthspan
A
- Various attitudes and practices around the world
- moral, ethical, religious implications
- Increasing lifespan can decrease healthspan
- decreasing lifespan can increase healthspan
6
Q
Risk factors that decrease lifespan
A
- Weight/build
- amounts of exercise
- stress
- sleep
- education level
- blood pressure
- genetics, etc.
7
Q
Biomarkers
A
What helps to objectively track aging/disease and are indicators of the biological state of the organism
8
Q
Height - Biomarker
A
- Increases throughout infancy then begins decreasing at 40
- Shortens with bone degradation/ compression of the spine
- There is a normal range and an abnormal range to losing height
9
Q
Muscle Mass - Biomarker
A
- Starts decreasing at 40 (up to 1% loss per year)
- Slowed down by lifting weights
- Males: associated with decrease in testosterone
- Females; associated with inactivity and estrogen levels
- To prevent loss of muscle mass resistance training is important and protein in diet
10
Q
Requirements of a Biomarker
A
- Predicts rise of future development of disease or level of current disease
- accurate and precise measurement
11
Q
New Era of Biomarkers
A
- Networks within organs are interrupted during disease statues
- Panels of blood markers
- Reductionist model: systems biology approach would consider complexity of molecular networks to determine the presence of disease
