Biological Explanation Of Unipolar Depression (AO2): Depression

Question 1

How might recognising the genetic aspect of depression be important for people with a history of depression in their families?

Answer 1

It alerts them that they’re at higher risk of developing the disorder themselves. Based on this information, they could avoid occupations which are stressful or avoid using drugs that might trigger the condition. If the symptoms are recognised early enough, the disorder could be managed more effectively.

Question 2

Understanding the link between schizophrenia and serotonin has led to the development of…

Answer 2

…effective antidepressant drugs, like monoamine oxidase inhibitors (MAOIs). These inhibit MAO-A and reduce depressive symptoms.

Question 3

Why is research into the 5-HTT gene important?

Answer 3

Drugs only mask the symptoms of depression and have unpleasant side-effects. Research into 5-HTT gene offers hope that future therapies could increase the levels of serotonin in individuals who show early symptoms of depression, which could prevent depression from developing in the first place.

Question 4

Why must we be careful about interfering with the MAO-A process?

Answer 4

MAO-A is a good thing that helps a healthy brain work efficiently. High levels of MAO-A are linked to uncontrollable aggression.