Biological And Biochemical Foundations Of Living Systems Flashcards
GAP catalyzes the conversion of Arf1-bound GTP to
GDP and inorganic phosphate
Hydrolysis of the γ phosphate of GTP bound to Arf1 results in:
It’s inactivation
The Arf1-activating molecule GTP is most closely related to which family of biomolecules
Nucleotides because GTP stands for guanosine triphosphate (a nucleotide)
GAP belongs to what class of enzymes?
Phosphatase
Phosphatases are responsible for
the cleavage of phosphate bonds utilizing water to remove a molecule of inorganic phosphate
Transferases are responsible for
transferring of functional groups between molecules
Kinases are responsible for
adding of phosphate groups to molecules.
Isomeases
rearranging of the structure of molecules.
Proteins that are encapsulated in Arf1-COP derived vesicles are bound for the:
Endoplasmic reticulum because Arf1 is responsible for the retrograde (backwards) movement for the Golgi apparatus causing it to go back
Proteins that are encapsulated in Arf1-COP derived vesicles transporting steps:
cytoplasm->endoplasmic reticulum->Golgi apparatus->cell membrane
Based on the mode of action described for BFA in the passage, the drug would be most effective against
Eukarya because it has a Golgi apparatus
Archaea, viruses, and bacteria do not have
A golgi apparatus
BFA inhibits _____ resulting in ______
Arf1-driven vesicle formation ; reversible disruption of the Golgi apparatus
The function of the beta subunit involves
adhering neutrophils to the endothelium
Because during injury neutrophils adhere to the endothelium and an antibody generated toward the beta subunit is able to reduce the damage of neutrophils to the endothelium. This antibody is most likely to inhibit the interaction between the neutrophils and the endothelial cells.
As an antibody was produced in another organism….(clinically treat humans)
several uses might trigger an immune response in the human individuals that would recognize the molecule as foreign.
