Biological Agents

Question 1

What is the target and use(s) of:

Adalimumab, infliximab, etanercept

Answer 1

• TNF alpha inhibitor

- Crohns & RA

Question 2

What is the target and use(s) of:

Bevacizumab

Answer 2

• Anti VEGF (anti angiogenic)

- Colorectal & renal cancer, glioblastoma

Question 3

What is the target and use(s) of:

Trastuzumab

Answer 3

• HER receptor

- Breast cancer

Question 4

What is the target and use(s) of:

Imatinib

Answer 4

• Tyrosine kinase inhibitor

- GI stromal tumours, CML

Question 5

What is the target and use(s) of:

Basilliximab

Answer 5

• IL2 binding site

- Renal transplants

Question 6

What is the target and use(s) of:

Ceftuximab

Answer 6

• Epidermal growth factor inhibitor

- EGF +ve colorectal cancers