biofuckingchemistry Flashcards
why do alcoholics have a problem with the link reaction
Pyruvate dehydrogenase complex is made of 3 enzyme all of whom require vit Bs which are chronically deficient in alcoholics(normally)
what is the link reaction
pyruvate + CoA +NAD+ -> Acetyl CoA + NADH + CO2
what are insulin receptors
dimerised tyrosine kinase receptors
what is the role of AKT in the liver
activate glycogenesis
re lipogenesis, discuss insulin
inhibits HSL (lipolysis)
upregulates lipogenic gene expression
what is beta oxidation of FAs
FA is converted to Fatty Acyl CoA at cell membrane
CAT 1 gets rid of CoA and attaches shuffle
transported by Carnatine shuffle to inner mitochondrial membrane
reconnected with new CoA by CAT2
OHOT to acetyl CoA
where does beta oxidation not happen
brain and rbc
what is palmitic acid
FA with 16 carbons
what are the electron receivers in OHOT
1 x NAD+, 1 x FAD+
which enzyme regulates the carnatine shuffle
CAT1
symptoms of CAT1 problems
muscle cramps, fatigue
what activates/inhibits CAT1
A: fasting state, glucagon, cAMP
I: fed state, insulin, MALONYL COA DON’T FORGET
what does malonyl CoA do a lot of
=fed state, inhibits gluconeogenesis, glycogenlysis, lipolysis etc
where does lipogenesis happen
liver, adipose tissue, lactating mammary glands
what’s the deal with IgA and breast milk
babies don’t have IgA, something about alpha4beta7 Madcam1
