bioelectricity Flashcards
1
Q
Itotal
A
total current flow across the whole membrane = sum of currents through each open channel
2
Q
FHEIG
A
bi-temporal narrowing hypertrichosis thin upper lip bushy eyebrows overgrowth of tissues inside mouth delayed development of motor skills + intellectual ability seizures
3
Q
what is FHEIG caused by?
A
GOF mutation in KCNK4 = K+ channel
widely expressed in CNS and PNS
larger currents
excess loss of K+ into interstitial space -> K+ accumulates in interstitial space
nernst potential for K+ is less negative
resting membrane potential and neighbouring cells’ resting membrane potential more depolarised
closer to threshold
easier to fire AP
