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Physiology > Biochemistry Proteins/Prions > Flashcards

Biochemistry Proteins/Prions Flashcards

0
Q

A form of TSE that affects young males and females?

A

vCJD

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1
Q

What composes the primary structure of proteins?

A

Amino acids

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2
Q

Gene responsible for Prion susceptibility

A

PRNP

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3
Q

A higher order of protein structure composed of multiple domains

A

Tertiary structure

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4
Q

Protein in RBCs that gives its characteristic pinkish tint

A

Heme

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5
Q

Histoblot technique for Lipids

A

Fareast blot

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6
Q

Beta sheets that run towards opposite directions

A

Anti parallel

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7
Q

Y/N: can proteins renature after being denatured by Sodium Dodecylsulfate

A

No

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8
Q

Quaternary structure is also called

A

Polypeptides

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9
Q

What histoblot technique will you use if you want to check if a person is susceptible to prion-related diseases?

A

Northern blot

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10
Q

Composition of PrPc?

A

3 alpha helices and 2 beta sheets

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11
Q

Inherited TSEs are in what type of heredity?

A

Autosomal dominant

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12
Q

Chromosome where the PRNP gene is located

A

C20

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13
Q

The most common form of an alpha helix

A

Right handed

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14
Q

Plot that measures the prevalence of alpha helices and beta sheets

A

Ramachandran plot

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15
Q

Histoblot technique that detects proteins

A

Western blot

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16
Q

What type of pairing of codon 129 of PRNP gene that makes susceptibility to prion disease increase

A

Homozygosity

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17
Q

Heterozygosity of codon 129 gives resistance to prion disease. T/F

A

True

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18
Q

Defective proteins in the cell is tagged for degradation by…

A

Ubiquitin

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19
Q

Was prevalent in Europe that made TSEs a worldwide topic

A

Mad cow’s disease / BSE

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20
Q

Who coined the term prion

A

Prusiner

21
Q

Leucine zipper is what type of protein structure?

A

Secondary super structure

22
Q

What makes secondary super structures?

A

Loops and bends

23
Q

Histoblot technique that detects DNA

A

Southern blot

24
Q

The result of translation

A

Amino acids

25
Q

What process is the conversion of PrPc to PrPsc called?

A

Post translational modifications

26
Q

T/F: all proteins have a quaternary structure

A

False

27
Q

Mutations to genes will affect what protein structure initially?

A

Primary

28
Q

Changes in secondary or tertiary structure affect its function. T/F

A

True

29
Q

PrPsc conversion is reversible. T/F

A

True

30
Q

PrPc conversion normally occurs in humans. T/F

A

True

31
Q

Where does protein synthesis occur?

A

RER and ribosomes

32
Q

The structure of integral proteins

A

Helix

33
Q

Major composition of the cell membrane

A

Proteins

34
Q

Globular proteins is abundant of what type of secondary structure?

A

Beta sheet

35
Q

Functional units that make up the tertiary structure

A

Domains

36
Q

Are all enzymes proteins?

A

No

37
Q

Are all proteins enzymes?

A

No

38
Q

T/F: prion disease is due to primary structure alteration

A

False

39
Q

T/F: prion is a quaternary structure

A

False

40
Q

Can proteins be broken down to its component amino acids? Y/N

A

Yes

41
Q

Prion disease was first observed in…

A

Papua New Guinea

42
Q

TSE stands for?

A

Transmissible Spongiform Encelopathy

43
Q

Are all encelopathies due to prions?

A

No

44
Q

Are prion and related disease curable?

A

No

45
Q

Biopsy of what structure can you detect PrPsc among young people with vCJD?

A

Tonsil

46
Q

What is the central dogma

A

Replication>transcription>translation

47
Q

Proteins is an essential part of our diet? Y/N

A

Yes

48
Q

Protein structure deformity of the globulin group of hemoglobin will result to…

A

Anemia

49
Q

Prion is a shorter term for….

A

Proteinaceous infectious agent

Physiology (3 decks)

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