Biochemistry of Coagulation--Goueli

Question 1

Mechanism of heparin

Answer 1

binds ATIII (antithrombin III)

–> increases ATIII activity

–> ATIII binds thrombin and Xa

Question 2

MOA warfarin

Answer 2

Vitamin K antagonist

prevents several clotting factor synthesis

**also blocks protein C and S

–> they normally have anti-coagulation properties

NEED A HEPARIN BRIDGE WHEN STARTING WARFARIN

Question 3

Function of vWF

Answer 3

bridges Ib and collagen