Biochemistry

Question 0

Biochemical picture in abnormal kidney function

Answer 0

Low GFR:
High urea, creatinine, K+ H+, urate, phosphate.
Low Ca2+ and HCO3
Increased anion gap

Tubular dysfunction: 
Low K+, urate, phosphate, HCO3
High H+
Urea and creatinine normal
Protein and glucose also present

Question 1

Blood results in dehydration

Answer 1

Raised urea disproportionate to increase in creatinine
High albumin

Clinically - reduced urine output and skin turgor

Question 2

Electrolyte changes in pts on thiazide or loop diuretics

Answer 2

Low Na and K

Raised HCO3 and urea

Question 3

U+E in pt with Addisons

Answer 3

High K
Low Na
High urea

Question 4

U+E in pt with Cushings

Answer 4

Low K
High HCO3
High Na

Question 5

U+E in Conn’s syndrome

Answer 5

Low K
High HCO3

Na normal or high