Biochemical Defense Systems

Question 1

Glutathione

Answer 1

Glutathione is the body’s main antioxidant defense mechanism produced in the liver.

It protects against free radicals and helps to eliminate lipid peroxides as well as toxins. This is by far more powerful than antioxidant supplements or vitamins because the body will self-regulate glutathione’s role in the immune system.

Question 2

NRF2 PATHWAY

Answer 2

Nrf2 is one of the main regulators of antioxidants and cell protection. It promotes glutathione, NADPH, thioredoxin and other antioxidant pathways.

Regular exercise stimulates the body’s defense mechanisms and strengthens immunity by activating Nrf2.

The ketogenic diet activates the Nrf2 pathway that lowers inflammation and oxidative stress.

Question 3

Autophagy

Answer 3

Cellular self-eating modulates immunity and elimination of pathogens via autophagy.

The body recognizes damaged cells and recycles them.

Autophagy gets triggered in response to stress like infections, starvation, high exertion or certain compounds such as various phytochemicals.

You can promote autophagy with positive stressors such as intermittent fasting, regular sauna, exercise and cold exposure

Question 4

Nicotinamide adenine dinucleotide (NAD+)

Answer 4

Nicotinamide adenine dinucleotide (NAD+) is a major cofactor that partakes in virtually all cellular reactions.

It promotes energy production and enables cells to work properly.

NAD+ deficiencies are linked to aging and disease.
Low NAD+ is also known to inhibit the body’s immune system and natural defense mechanisms.

Question 5

Uric acid

Answer 5

Uric acid is the most concentrated antioxidant in the human blood that helps to mitigate oxidative stress, especially at high altitudes and under hypoxia.

In high amounts it can cause gout and fibromyalgia, but in low concentrations it is actually beneficial.

You obtain it from purine-rich foods like organ meat, wild game, red meat and seafood.

Question 6

Nitric oxide (NO)

Answer 6

Nitric oxide (NO) is an important signaling molecule between cells and it has been shown to fight against some viral and bacterial infections.

Supplementation with NO boosters (for example L-arginine and L-citrulline as well as foods rich in nitrates such as beets and leafy greens) may inhibit viral replication cycles (e.g. SARS coronavirus).

Note that when used excessively, arginine can activate an unde lying herpes infection when intake of L-lysine is also low.

Question 7

Biochemical Defense Systems

Answer 7

Biochemical Defense Systems modulate the immune system and increase resilience against disease.