Biochem Uni 3

Question 1

Fed state

Answer 1

• absorption takes place in the intestines.
• glucose and amino acids reach the portal circulation
• chylomicrons will reach the lymphatics and through that they will reach the systemic circulation
• The glucose will enter LIVER AND PANCREAS first which do not require insulin to promote glucose uptake.

Question 2

What is the affect of glucose on beta cells?

Answer 2

Leads to the release of insulin:

• glucose increases the ATP ratio and the ATP will close potassium channels
• voltage changes after K+ channels close lead to Ca2+ channels opening which leads to the degranulation and insulin release

Question 3

In liver, uptake of glucose does not require insulin. What are the transporters used in the liver?

Answer 3

GLUT 2