Biochem Session 4

Question 1

what can irreversible inhibitors be used for

Answer 1

to map the active sites of enzymes. Irreversible inhibitors bind very tightly to enzymes. irreversible inhibitors that bind the enzyme covalently are powerful tools for elucidating the mechanisms of enzyme action

Question 2

how is gout related to feedback inhibition

Answer 2

it is a genetic mutation that alters feed back allosteric inhibition of an enzyme involved in nucleotide synthesis, causing an increase in uric acid