Biochem Flashcards
LDL
Transports cholesterol from liver to tissues
HDL
Transport cholesterol from periphery to liver
Chylomicrons
Deliver TGs to peripheral tissue
Deliver cholesterol to liver
VLDL
Deliver TGs to peripheral tissue
IDL
Deliver TGs and cholesterol to liver
ApoB-48
Chylomicron secretion from enterocyte to lymphatic system
ApoB-100
Found on VLDL, IDL, LDL
ApoE
Mediates extra remnant uptake
ApoA-I
Activates LCAT, found on HDL
ApoC-II
Cofactor for lipoprotein lipase
Abetalipoproteinemia
AR, decreased ApoB-48 and ApoB-100
Mutation of MTP gene
Decreased chylomicron and VLDL synthesis and secretion
Abetalipoproteinemia symptoms
Steatorrhea (fat malabsorption)
Ataxia
Night blindness (fat soluble vitamins malabsorption)
Abetalipoproteinemia histology
Enterocytes swollen with TGs
Acanthocytosis of RBCs
Abetalipoproteinemia treatment
Vit E
Type I hyperchylomicronemia
AR
Lipoprotein lipase deficiency or defective ApoC-II
Increased chylomicrons, TGs, cholesterol
Type I hyperchylomicronemia presentation
Pancreatitis
Hepatosplenomegaly
Pruritic xanthomas
No increased risk for artherosclerosis
Type IIa familial hypercholesterolemia
AD
Absent or decreased LDL receptors
Type IIa familial hypercholesterolemia presentation
Tendinous xanthomas
Corneal arcus
Accelerated atherosclerosis
MI
Type IV hypertriglyceridemia
AD
Overproduction of VLDL
Pancreatitis
