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DIT > Biochem > Flashcards

Biochem Flashcards

1
Q

LDL

A

Transports cholesterol from liver to tissues

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2
Q

HDL

A

Transport cholesterol from periphery to liver

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3
Q

Chylomicrons

A

Deliver TGs to peripheral tissue

Deliver cholesterol to liver

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4
Q

VLDL

A

Deliver TGs to peripheral tissue

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5
Q

IDL

A

Deliver TGs and cholesterol to liver

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6
Q

ApoB-48

A

Chylomicron secretion from enterocyte to lymphatic system

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7
Q

ApoB-100

A

Found on VLDL, IDL, LDL

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8
Q

ApoE

A

Mediates extra remnant uptake

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9
Q

ApoA-I

A

Activates LCAT, found on HDL

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10
Q

ApoC-II

A

Cofactor for lipoprotein lipase

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11
Q

Abetalipoproteinemia

A

AR, decreased ApoB-48 and ApoB-100
Mutation of MTP gene
Decreased chylomicron and VLDL synthesis and secretion

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12
Q

Abetalipoproteinemia symptoms

A

Steatorrhea (fat malabsorption)
Ataxia
Night blindness (fat soluble vitamins malabsorption)

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13
Q

Abetalipoproteinemia histology

A

Enterocytes swollen with TGs

Acanthocytosis of RBCs

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14
Q

Abetalipoproteinemia treatment

A

Vit E

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15
Q

Type I hyperchylomicronemia

A

AR
Lipoprotein lipase deficiency or defective ApoC-II
Increased chylomicrons, TGs, cholesterol

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16
Q

Type I hyperchylomicronemia presentation

A

Pancreatitis
Hepatosplenomegaly
Pruritic xanthomas

No increased risk for artherosclerosis

17
Q

Type IIa familial hypercholesterolemia

A

AD

Absent or decreased LDL receptors

18
Q

Type IIa familial hypercholesterolemia presentation

A

Tendinous xanthomas
Corneal arcus
Accelerated atherosclerosis
MI

19
Q

Type IV hypertriglyceridemia

A

AD
Overproduction of VLDL
Pancreatitis

DIT (3 decks)

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