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Biocemistry - Regulation Flashcards

1
Q

Phosphofructokinase-1 (PFK-1) - Regulation

A

Positive:
AMP
fructose-2,6-bisphosphate

Negative:
ATP
citrate

CAFA!

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2
Q

Fructose-1,6-bisphosphatase - Regulation

A

Positive:
Citrate

Negative:
AMP
fructose-2,6-bisphosphate

CAF!

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3
Q

lsocitrate dehydrogenase - Regulation

A

Positive:
ADP

Negative:
ATP
NADH

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4
Q

Glycogen synthase - Regulation

A

Positive:
G - Glucose-6-phosphate
I - insulin
C - cortisol

Negative:
Epinephrine
glucagon

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5
Q

Glycogen phosphorylase - Regulation

A

Positive:
A - AMP
G - glucagon
E - Epinephrine

Negative:
A - ATP
G - Glucose-6-phosphate
I - insulin

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6
Q

Glucose-6-phosphate dehydrogenase (G6PD) - Regulation

A

Positive: NADP+

Negative: NADPH

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7
Q

Carbamoyl phosphate synthetase II - Regulation

A

Positive:
ATP
PRPP

Negative:
UTP

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8
Q

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase - Regulation

A

Negative:
AMP
inosine monophosphate (IMP)
GMP

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9
Q

Carbamoyl phosphate synthetase I - Regulation

A

Positive: N-acetylglutamate

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10
Q

Acetyl-CoA carboxylase (ACC) - Regulation

A

Positive:
Insulin
citrate

Negative:
Glucagon
palmitoyl-CoA

“I Can’t Get Palmolive”

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11
Q

Carnitine acyltransferase I - Regulation

A

Negative: Malonyl-CoA

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12
Q

HMG-CoA reductase - Regulation

A

Positive:
T - thyroxine
I -Insulin
E - estrogen

Negative:
Glucagon
cholesterol

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13
Q

Glycolysis - Rate determining enzyme

A

Phosphofructokinase-1 (PFK-1)

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14
Q

Gluconeogenesis - Rate determining enzyme

A

Fructose-1,6-bisphosphatase

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15
Q

TCA cycle - Rate determining enzyme

A

lsocitrate dehydrogenase

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16
Q

Glycogenesis - Rate determining enzyme

A

Glycogen synthase

17
Q

Glycogenolysis - Rate determining enzyme

A

Glycogen phosphorylase

18
Q

HMP shunt - Rate determining enzyme

A

Glucose-6-phosphate dehydrogenase (G6PD)

19
Q

De novo pyrimidine synthesis - Rate determining enzyme

A

Carbamoyl phosphate synthetase II

20
Q

De novo purine synthesis - Rate determining enzyme

A

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase

21
Q

Urea cycle - Rate determining enzyme

A

Carbamoyl phosphate synthetase I

22
Q

Fatty acid synthesis - Rate determining enzyme

A

Acetyl-CoA carboxylase (ACC)

23
Q

Fatty acid oxidation - Rate determining enzyme

A

Carnitine acyltransferase I

24
Q

Ketogenesis - Rate determining enzyme

A

HMG-CoA synthase

25
Q

Cholesterol synthesis - Rate determining enzyme

A

HMG-CoA reductase

26
Q

Pyruvate Kinase - Regulation

A

Positive:
Fructose-1,6-bisphosphate

Negative:
ATP
Alanin

My step 1 mnemonics (19 decks)

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