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Bioactive Lipids Flashcards

1
Q

dereivative that has a biology effect

A

bioactive lipids

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2
Q

breakdown product of arachidonic acid

A

bioactive lipids

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3
Q

diverse physical, chemical, inflammatory and mitogenic stimuli

A

Help bring arachidonic acid into the cell

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4
Q

3 enzymes that reduce Arachiodonic acid (AA)

A

Cytochrome p450
LOX (Lipoxygenases)
COX (Cycloxygenases)

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5
Q

Cytochrome p450 breaks AA into

A

EETs (Epoxyeicosatrienoic acids)

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6
Q

LOX breaks AA into

A

HETEs
Leukotrienes (** Most important)
Lipoxins

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7
Q

COX breaks AA into

A

Prostanoids: such as -
Prostaglandins ()
Prostacyclin
Thromboxane ()

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8
Q

constitutively expressed in most cells

A

COX1

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9
Q

inducible, expression varies based on stimulus

A

COX2

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10
Q

proposed (can be inhibited in acetaminophen)

A

COX3

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11
Q

when macrophages become activated, they increase their expression of ___

A

COX2

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12
Q

Subtypes of Prostaglandins

A

PGE2
PGFa
PGD2
PGI1

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13
Q

Subtype of Thromboxane

A

TXA2

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14
Q

vasodilator produced by endothelium

A

PGE2

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15
Q

contracts longitudinal GI smooth muscle, relaxes circular GI smooth muscle

A

PGE2

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16
Q

Bronchodilator

A

PGE2

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17
Q

low concentrations enhance platelet activity, high concentrations inhibit

A

PGE2

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18
Q

vasodilator in kidney, plays a role in maintaining renal blood flow and GFR

A

PGE2

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19
Q

low concentrations cause uterine contraction, high concentrations relax

A

PGE2

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20
Q

pyrogen, can be used as an abortifacient in second trimester

A

PGE2

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21
Q

promotes inflammation

A

PGE2

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22
Q

increase bone turnover

A

PGE2

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23
Q

lowers intraocular pressure

A

PGE2

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24
Q

pro-oncogenic

A

PGE2

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25
synthetic PGE2 used to ripen cervix prior to labor induction
DINOPROSTONE
26
synthetic PGE1 used with mifepristone (RU 486) as abortifacient
MISOPROSTOL
27
can be used to treat NSAID induced ulcers
MISOPROSTOL
28
abortion pill
MIFEPRISTONE
29
vasocontrictor (prostanoid subtype)
PGF2A
30
contracts longitudinal and circular GI smooth muscle
PGF2A
31
bronchoconstrictor (prostanoid subtype)
PGF2A
32
uterine contraction and onset (along with oxytocin) of partiurition
PGF2A
33
pyrogen (prostanoid subtype)
PGF2A
34
lower intraocular pressure
PGF2A
35
derivative used extensively to treat glacoma
LATANOPROST
36
vasodilator (prostanoid subtype)
PGI2
37
bronchodilator (prostanoid subtype)
PGI2
38
decreases uterine tone
PGI2
39
inhibits platelet aggregation
PGI2
40
used to treat severe pulmonary hypertension and as anticoagulant in dialysis machines
EPOPROSTENOL
41
potent vasocontrictor and bronchoconstrictor
Thromboxane A2
42
increase uterine tone
Thromboxane A2
43
platelet activator - causes thrombosis
Thromboxane A2
44
primary physiological effects of leukotriene pathway appear to be mediated by __ and __
LTC4 and LTD4
45
5-LOX inhibitor
ZILEUTON
46
LTD4 receptor antagonists
ZAFIRLUKAST and MONTELUKAST
47
primary physiological effects appear to be potent bronchoconstriction and activation of ___
leukocyte chemotaxis
48
decreased formation or antagonism of receptor binding are major therapeutic strategies employed in ___
asthma
49
decreased phospholipase A activity (decrease AA production)
cortiocsteroids
50
decrease COX2 synthesis
corticosteroids
51
nonselective vs selective COX inhibitors
NSAIDS
52
replace AA with dietary fatty acids
PUFA Polyunsaturated fatty acids
53
prototypic nonselective
Aspirin
54
selective COX2
Celecoxib
55
causes irreversible inhibition of COX receptors
Aspirin
56
main COX in the stomach
COX1
57
side step the induced ulcers effect
COX2
58
what are the 2 pyrogens?
PGE2 | PGF2a
59
Which lowers intraocular pressure?
PGE2 | PGF2a
60
Which is a dilator?
PGE2
61
Which is a constrictor?
PGF2
62
Which contracts longitudinal GI SM but relaxes it?
PGE2
63
which has uterus effects but not platelet effects?
PGF2a

Pharm (6 decks)

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