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Pharm > Bioactive Lipids > Flashcards

Bioactive Lipids Flashcards

1
Q

dereivative that has a biology effect

A

bioactive lipids

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2
Q

breakdown product of arachidonic acid

A

bioactive lipids

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3
Q

diverse physical, chemical, inflammatory and mitogenic stimuli

A

Help bring arachidonic acid into the cell

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4
Q

3 enzymes that reduce Arachiodonic acid (AA)

A

Cytochrome p450
LOX (Lipoxygenases)
COX (Cycloxygenases)

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5
Q

Cytochrome p450 breaks AA into

A

EETs (Epoxyeicosatrienoic acids)

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6
Q

LOX breaks AA into

A

HETEs
Leukotrienes (** Most important)
Lipoxins

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7
Q

COX breaks AA into

A

Prostanoids: such as -
Prostaglandins ()
Prostacyclin
Thromboxane ()

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8
Q

constitutively expressed in most cells

A

COX1

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9
Q

inducible, expression varies based on stimulus

A

COX2

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10
Q

proposed (can be inhibited in acetaminophen)

A

COX3

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11
Q

when macrophages become activated, they increase their expression of ___

A

COX2

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12
Q

Subtypes of Prostaglandins

A

PGE2
PGFa
PGD2
PGI1

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13
Q

Subtype of Thromboxane

A

TXA2

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14
Q

vasodilator produced by endothelium

A

PGE2

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15
Q

contracts longitudinal GI smooth muscle, relaxes circular GI smooth muscle

A

PGE2

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16
Q

Bronchodilator

A

PGE2

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17
Q

low concentrations enhance platelet activity, high concentrations inhibit

A

PGE2

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18
Q

vasodilator in kidney, plays a role in maintaining renal blood flow and GFR

A

PGE2

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19
Q

low concentrations cause uterine contraction, high concentrations relax

A

PGE2

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20
Q

pyrogen, can be used as an abortifacient in second trimester

A

PGE2

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21
Q

promotes inflammation

A

PGE2

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22
Q

increase bone turnover

A

PGE2

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23
Q

lowers intraocular pressure

A

PGE2

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24
Q

pro-oncogenic

A

PGE2

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25
Q

synthetic PGE2 used to ripen cervix prior to labor induction

A

DINOPROSTONE

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26
Q

synthetic PGE1 used with mifepristone (RU 486) as abortifacient

A

MISOPROSTOL

27
Q

can be used to treat NSAID induced ulcers

A

MISOPROSTOL

28
Q

abortion pill

A

MIFEPRISTONE

29
Q

vasocontrictor (prostanoid subtype)

A

PGF2A

30
Q

contracts longitudinal and circular GI smooth muscle

A

PGF2A

31
Q

bronchoconstrictor (prostanoid subtype)

A

PGF2A

32
Q

uterine contraction and onset (along with oxytocin) of partiurition

A

PGF2A

33
Q

pyrogen (prostanoid subtype)

A

PGF2A

34
Q

lower intraocular pressure

A

PGF2A

35
Q

derivative used extensively to treat glacoma

A

LATANOPROST

36
Q

vasodilator (prostanoid subtype)

A

PGI2

37
Q

bronchodilator (prostanoid subtype)

A

PGI2

38
Q

decreases uterine tone

A

PGI2

39
Q

inhibits platelet aggregation

A

PGI2

40
Q

used to treat severe pulmonary hypertension and as anticoagulant in dialysis machines

A

EPOPROSTENOL

41
Q

potent vasocontrictor and bronchoconstrictor

A

Thromboxane A2

42
Q

increase uterine tone

A

Thromboxane A2

43
Q

platelet activator - causes thrombosis

A

Thromboxane A2

44
Q

primary physiological effects of leukotriene pathway appear to be mediated by __ and __

A

LTC4 and LTD4

45
Q

5-LOX inhibitor

A

ZILEUTON

46
Q

LTD4 receptor antagonists

A

ZAFIRLUKAST and MONTELUKAST

47
Q

primary physiological effects appear to be potent bronchoconstriction and activation of ___

A

leukocyte chemotaxis

48
Q

decreased formation or antagonism of receptor binding are major therapeutic strategies employed in ___

A

asthma

49
Q

decreased phospholipase A activity (decrease AA production)

A

cortiocsteroids

50
Q

decrease COX2 synthesis

A

corticosteroids

51
Q

nonselective vs selective COX inhibitors

A

NSAIDS

52
Q

replace AA with dietary fatty acids

A

PUFA

Polyunsaturated fatty acids

53
Q

prototypic nonselective

A

Aspirin

54
Q

selective COX2

A

Celecoxib

55
Q

causes irreversible inhibition of COX receptors

A

Aspirin

56
Q

main COX in the stomach

A

COX1

57
Q

side step the induced ulcers effect

A

COX2

58
Q

what are the 2 pyrogens?

A

PGE2

PGF2a

59
Q

Which lowers intraocular pressure?

A

PGE2

PGF2a

60
Q

Which is a dilator?

A

PGE2

61
Q

Which is a constrictor?

A

PGF2

62
Q

Which contracts longitudinal GI SM but relaxes it?

A

PGE2

63
Q

which has uterus effects but not platelet effects?

A

PGF2a

Pharm (6 decks)

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