Adrenoceptor antagonist 1!!

Question 1

which adrenoceptor antagonist (receptor) is used for hypertension and prostatic hyperplasia?

Answer 1

alpha 1

Question 2

Which adrenoceptor does not have many clinical uses?

Answer 2

alpha 2

Question 3

Mixed Alpha 1&2 adrenoceptor antagonists are commonly used for?

Answer 3

pheochromocytoma

Question 4

Which adrenoceptor antagonists are used for hypertension, arrhythmia, ischemic, heart disease, endocrine and neurologic disorders, glaucoma?

Answer 4

Beta antagonists

Question 5

Which adrenoceptor antagonists are sympatolytic?

Answer 5

mixed antagonists alpha & beta

Question 6

Which antagonists cause a lowering of peripheral vascular resistance and blood pressure?

Answer 6

alpha antagonists

Question 7

Which drugs can prevent the pressor effects of alpha agonists? What are they called?

Answer 7

alpha antagonists

called an “epinephrine reversal”

Question 8

What often causes postural hypotension and bradycardia?

Answer 8

alpha antagonists

Question 9

What is the genitourinary effects of alpha antagonists?

Answer 9

decreased resistance to urine flow and can help with urinary retention (especially due to an enlarged prostate)

Question 10

Which adrenoceptor antagonist drug is used in the management of hypertension?

Answer 10

Prazosin - highly selective for alpha-1- receptors

Question 11

What does Prazosin not have an effect on?

Answer 11

Does NOT have tachycardic effect of phentolamine or phenoxybenzamine

Question 12

Which adrenoceptor antagonist drug is used to treat BPH (benign prostatic hyperplasia)?

Answer 12

Terazosin

Question 13

Which adrenoceptor antagonist drug is used to hypertension and BPH (benign prostatic hyperplasia)?

Answer 13

Doxazosin

Question 14

Which three alpha antagonistic drugs have a higher affinity for alpha 1 over alpha 2?

Answer 14

Prazosin, terazosin, doxazosin

Question 15

Which drug has a longer half life than Prazosin or Terazosin?

Answer 15

Doxazosin

Question 16

Which adrenoceptor antagonist is a great drug for BPH because it inhibits the prostatic smooth muscle? When does it have a less dramatic effect on Blood Pressure?

Answer 16

Tamsulosin (Flowmax)

Less dramatic effect on BP in standing patients

Question 17

Tamsulosin (Flowmax) is a competitive ______ antagonist.

Answer 17

Alpha 1 antagonist

Question 18

Which andrenoreceptor antagonist drug causes blockade of long duration at alpha receptors?

Answer 18

Phenoxybenzamine

Question 19

Which adrenoceptor is phenoxybenzamine selective for?

Answer 19

Alpha-1 (but less so than Prazosine)

Question 20

What receptors does phenoxybenzamine block?

Answer 20

histamine, acetylcholine, and serotonin receptors

Question 21

Which adrenoreceptor antagonist causes severe hypotension when patient is upright?

Answer 21

Phenoxybenzamine

Question 22

What does Phenoxybenzamine inhibit the reuptake of?

Answer 22

norepinephrine

Question 23

Which adrenoreceptor antagonistic drug is used to treat pheochromocytoma?

Answer 23

Phenoxybenzamine and Phentolamine

Question 24

What are the adverse effect of Phenoxybenzamine?

Answer 24

1. postural hypotension & tachycardia
2. nasal stuffiness
3. inhibition of ejaculation

Question 25

Which adrenoreceptor antagonist is a potent competitive antagonist of both alpha1 and alpha 2 receptors and leads to enhanced release of norephinephrine and thus stimulates the heart?

Answer 25

Phentolamine

Question 26

What are the adverse effects of Phentolamine?

Answer 26

1. tachycardia 2. arrhythmias 3. MI 4. Headache 5. nasal congestion

Question 27

What is used to treat pheochchromocytoma and male erectile dysfunction?

Answer 27

Phentolamine

Question 28

What is ALfuzosin used for?

Answer 28

alpha-1 selective drug used to treat BPH

Question 29

antihypertensive drug

Answer 29

Indoramin

Question 30

antihypertensive drug; also treats BPH; only used in Europe

Answer 30

Urapidil

Question 31

alpha and beta blocking capability

Answer 31

Labetolol

Question 32

an antidepressant that blocks alpha receptors

Answer 32

trazodone

Question 33

Alpha 2 selective agent with no specific clinical values as of yet

Answer 33

Yohimbine

Question 34

adrenal tumor characterized by episodic release of Epi (80%) and NE (20%)

Answer 34

Pheochromocytoma

Question 35

What is Labetalol still used for in emergencies?

Answer 35

hypertensive emergency

Question 36

What beta-receptor blocking drugs have intrinsic sympathomimetic properties?

Answer 36

partial agonsists

Question 37

T/F Beta Receptor Blocking Drugs that are selective for B1 vs B2 are dose related. Selectivity decreases at higher doses.

Answer 37

True

Question 38

What do all beta receptor blocking drugs have in common?

Answer 38

They all treat hypertension

Question 39

What ethnic class are beta receptor blocking drugs less efficacious in?

Answer 39

African Americans & Elderly

Question 40

What class of drugs has been shown to decreases portal vein pressure in patients with cirrhosis?

Answer 40

Beta receptor blocking drugs

Question 41

How do beta receptor blocking drugs effect blood pressure?

Answer 41

when used chronically beta receptor blocking drugs lower blood pressure in patients with hypertension

Question 42

T/F When given chronically, beta receptor blocking drugs will give lower BP in patients with hypertension, inhibit renin release, and always causes hypotension in a healthy individual.

Answer 42

FALSE! usually DONT cause hypotension in healthy individual

Question 43

WHen are cardiovascular effects of beta blockers most strongly indicated?

Answer 43

in the acute phase of a heart attatck

Question 44

What type of arrhythmias are beta blockers used to treat?

Answer 44

supraventricular and ventricular arrhythmias

Question 45

What are valuable for the heart following MI, angina, and CHF? (congestive heart failure)

Answer 45

Beta Blockers

Question 46

T/F Beta Blockers have positive ionotropic and negative chronotropic effects. Most cause tachycardia.

Answer 46

FALSEEE!!! 1. negative ionotropic & negative chronotropic effects 2. Most cause BRADYCARDIA

Question 47

T/F Beta Blockers lead to decreased air resistance, especially in patients with asthma.

Answer 47

FALSE! | increased airway resistance, especially with pt's with asthma

Question 48

What beta receptors are present in the bronchi?

Answer 48

B2

Question 49

Should beta blockers be avoided in asthmatics? why?

Answer 49

YES! they should be avoided, because the receptors are not completely selective.

Question 50

What type of patient with a respiratory disease could tolerate beta blockers? why?

Answer 50

Patients with COPD however may tolerate the drugs and risk/benefit ratio needs to be considered. i.e. a patient with COPD and severe ischemic heart disease

Question 51

What is the opthalmic effect of beta blockers?

Answer 51

reduce ocular pressure, especially in the eyes of patients with glaucoma

Question 52

What is the mechanism of the opthalmic effect of beta blockers?

Answer 52

they decreases the production of aqueous humor

Question 53

What receptor inhibits the stimulation of lipolysis?

Answer 53

Beta 3

Question 54

How do beta blockers effect cholesterol?

Answer 54

``` decrease HDL (the good cholesterol) and increase VLDL --may be less with ISA ```

Question 55

Due to the effects that beta blockers have on CHOLESTEROL .. what pt's should AVOID using beta blockers?

Answer 55

patients with CVD risk

Question 56

What is partially inhibited by beta blockers?

Answer 56

gycogenolysis

Question 57

Due to the effect that beta blockers have on glycogenolysis, what patients should avoid using beta blockers?

Answer 57

Diabetic patients, because glycogenolysis is the bodies defense against hypoglycemia

Question 58

What is the prototypical beta blocking drug?

Answer 58

Propanolol (Inderal)

Question 59

T/F Propanolol (Inderal) is selective for B1 receptors.

Answer 59

False - nonselective among beta receptor subtypes

Question 60

What is used in patients who have had an IM to prolong survival and protect the heart?

Answer 60

Propanolol (Inderal)

Question 61

T/F Propanolol (Inderal) has little effect on alpha receptors.

Answer 61

true

Question 62

What can be used during thyroid storm (severe hyperthyroidism) to control supraventricular tachycardia?

Answer 62

Propanolol (Inderal)

Question 63

T/F Propanolol (Inderal) is useless against migraines.

Answer 63

false- can reduce the frequency and intensity of migraines

Question 64

What is useful in patients who have suffered ischemic heart damage and also with CHF? What receptor is it selective for?

Answer 64

metoprolol (Lopressor) and Atenolol - B-1 selective drugs

Question 65

What beta blocker is safer to use in patient who suffer from asthma or COPD?

Answer 65

Metoprolol (Lopressor) & Atenoldol

Question 66

T/F Metoprolol (Lopressor), Atenolol, and Propanolol are useful in treating migraines.

Answer 66

true

Question 67

What is the most selective beta 1 antagonist?

Answer 67

Nebivolol

Question 68

What are the 3 things associated with Nebivolol?

Answer 68

1. vasodilator by increasing endothelial NO production 2. increase insulin sensitivity 3. No adverse effect on lipid profile

Question 69

What is a nonselective Beta blocker that has excellent ocular hypotensive effects when administered topically on the eye?

Answer 69

Timolol