Bio innovation Flashcards

1
Q

what is biomimetics

A

Biomimetics is the application of biological methods and
systems found in nature to the study and design of
engineering systems and modern technology.

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2
Q

how is shark skin used in airplanes

A

Shark skin is constructed of overlapping scales causing extreme efficiency to reach high speeds, shark skin coating can be applied on the wings of planes decreases drag and higher speeds, thus better fuel efficiency air bus uses and better handling of aircraft

The results of the use of riblets are a
reduction of the total drag, very imp

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3
Q

burr seeds and velcro

A

Small hooks enable seed-bearing burr to
cling to tiny loops in fabric.

Velcro was invented
Swiss engineer George de Mestral, who took
the idea from the burrs that stuck to his
dog’s hair.

he noted the tiny
hooks on the end of the burr’s spines that
caught anything with a loop - such as clothing, hair or animal fur

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4
Q

bullet train and kingfisher beak

A

the bullet train was intially very loud due to change in air pressure, from the shape of a bird’s beak to make it more
aerodynamic.

The resulting design was based on the narrow profile of a
kingfisher’s beak, resulting in a quieter train that also consumes 15% less electricity and goes 10% faster than before.

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5
Q

gecko and gecko tape

A

a nocturnal lizard which has
adhesive pads on the feet to assist in
climbing on smooth surfaces.
and walk along ceilings using fine hairs
on feet. lamella

Gecko Tape is a material covered with
nanoscopic hairs that mimic those found on the
feet of gecko lizards. that provide a powerful
adhesive effect.

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6
Q

butterfly wings and qualcomm screen

A

butterfly wings These tiny but complex structures reflect
light in such a way that specific
wavelengths interfere with each other to
create intensely vivid colors

Qualcomm have been able to
mimic this effect, allowing them to
develop a system that produces colored
electronic screens that are extremely
efficient and can be viewed under any
light conditions.

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7
Q

spider and robot spider

A

ability to squeeze through tight spaces
and turn on a dime makes the spider an ideal model for lifesaving robots that could
make their way through rubble after a disaster to locate survivors.

can be cheaply
reproduced using 3D printers.
for
it can help responders, for
instance by broadcasting live images or
tracking down hazards or leaking gas.

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8
Q

bio-inspired porous carbon

A

Bio-inspired porous carbon showed promising results regarding
their thermal protection of spacecrafts during the re-entry
process into planetary atmosphere

Space environment, presents a challenging setting due to existing
conditions of low to zero gravity, high temperature fluctuations,
elevated levels of UV, EM and particulate radiation,
reactive atomic oxygen, as well as natural micrometeoroids and
space debris.

Recently, researchers have developed lightweight and flexible materials for the protection of structures and equipment against
EM radiation
* Experiments show that EM interference can be
successfully shielded with these materials

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9
Q

pomelo fruit and space craft landing

A

Landing of unmanned spacecrafts on surface of another
planet is violent and associated with enormous impact forces.

Option of dealing with high impact forces is demonstrated by
the peel of the pomelo fruit.
Peel of the pomelo fruit demonstrates a thick layer with open cell foam structure of varying pore size which protects the
fruit inside from damage when falling from trees.
This impact damping and energy dissipating capabilities are
implemented in artificial versions of the foam to apply in space systems.

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10
Q

robotic system for space debris and octopi arms

A

As space debris has become a major concern,

  • Robotic systems inspired by octopi arms have already been
    proposed for space debris removal.
    great mobility, maneuverability and adaptability makes them
    very suitable to wrap around complex target shapes

Seahorses use their tail for grasping activities involving different
diameter objects.
provide great bending and torsion abilities for
grasping, especially of a diverse range of shapes and sizes,
their tails shows great fracture resistances under crushing and impact forces.

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11
Q

Plant based volatiles inspired packaging sachets – GreenPod
Labs

A

40% of fresh produce lost before it reaches consumers, Greenpod Labs have
created bio-inspired packaging sachets that mimic the built-in defense mechanisms
within specific fruits or vegetables, in order to slow down the ripening rate and minimize microbial growth. These are called plant-based volatiles, and the right
formulation reduces the need for cold storage and cold supply chains.

Nano structured inspired waterproof and breathable
Textiles – Amphibio

Using textiles made from one source material, made a
new recyclable and PFC-free alternative (sportswear etc)

Removing the need for any chemical treatments,

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12
Q

Embedding enzymes for better plastic degradation - Intropic
Materials

A

Intropic Materials is solving plastic waste by embedding enzymes
directly inside specific plastics to speed up natural degradation. These plastics break
down at the end of use into biodegradable or chemically recyclable small molecules
without producing microplastics, in -friendly conditions like warm water
baths or compost.

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13
Q

A biological neuron has three types of main components

A

dendrites,
soma (or cell body) and axon.
Dendrites receives signals from other neurons.
* The soma, sums the incoming signals. When sufficient input is received,
the cell fires; that is it transmit a signal over its axon to other cells.

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14
Q

how does a human brain work

A

In the human brain, a typical neuron collects signals from
others through a host of fine structures called dendrites.
● The neuron sends out spikes of electrical activity through a
long, thin stand known as an axon, which splits into
thousands of branches.
● At the end of each branch, a structure called a synapse
converts the activity from the axon into electrical effects
that inhibit or excite activity in the connected neurons.

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15
Q

Artificial Neural Network-ANN

A

is an information processing system
similar to biological nets

similar to biological neurons

The processing element receives many signals.
* Signals may be modified by a weight at the receiving synapse.
* The processing element sums the weighted inputs.
* Under appropriate circumstances (sufficient input), the
neuron transmits a single output.
* The output from a particular neuron may go to many other
neurons.

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16
Q

BIOINSPIRED ANN

A

are mathematical models inspired by the neural connections. Information processing occurs through simple elements called neurons. These neurons are connected by links, and each connection has a weight that determines the strength of the signal passed between neurons. The weight multiplies the signal as it is transmitted across the connection.

Each neuron receives inputs from other neurons, calculates the total weighted input by summing all incoming signals (each multiplied by its respective weight), and applies an activation function to decide its output. The activation function compares the total weighted input to a threshold value, which typically lies between 0 and 1. If the total weighted input is greater than or equal to the threshold, the neuron produces an output signal. Otherwise, no output is produced.

The strength of these connections, stored as weight values, changes during the learning process. Learning to solve a problem in an ANN involves adjusting the connection weights to improve the model’s ability to produce accurate outputs based on the examples or training data provided.

17
Q

BIOINSPIRED ANN layers

A

Input Layer - The activity of the input units represents the
raw information that is fed into the network.
● Hidden Layer - The activity of each hidden unit is
determined by the activities of the input units and the
weights on the connections between the input and the
hidden units.
● Output Layer - The behavior of the output units depends on
the activity of the hidden units and the weights between
the hidden and output units.
● This simple type of network is interesting because the
hidden units are free to construct their own representations
of the input.
● The weights between the input and hidden units determine
when each hidden unit is active, and so by modifying these
weights, a hidden unit can choose what it represents

18
Q

what is P-NET

A

P-NET is a neural network architecture that encodes different biological entities into a neural
network language with customized connections between consecutive layers (that is, features
from patient profile, genes, pathways, biological processes and outcome). The trained P-NET
provides a relative ranking of nodes in each layer to inform generation of biological
hypotheses. Solid lines show the flow of information from the inputs to generate the outcome
and dashed lines show the direction of calculating the importance score of different nodes.
Candidate genes are validated to understand their function and mechanism of action.

19
Q

different ANN models examples

A

Inspired by the five primary sensory systems (vision, touch, hearing,
smell, taste) in the human MSeNN (bioinspired spiking multisensory
neural network, and their interaction via neural networks,

Operational diagram of the artificial MSeNN
VERY IMP, they show graph and ask multiple choice using various sensors

another example:Illustration of the human ability to recognize and visualize audio input, Illustration of the human ability to recognize and visualize audio input

Detected image and vision memory of an apple, pear, blueberry, heart,into the
representations via the autoencoder to supervise the training of the ANN with
audio inputs.

20
Q

what are Biosensors and components in it, and what is Bio recognition

A

Analytical devices that combine biological detection components, such as a sensor system, with a transducer.

Components:
transducer(semi-conductor)
electronic system
(signal amplifier, processor)
display

Biosensor= analyte: a substance that aims to detection
ex: glucose is an ‘analyte’ in a biosensor designed to detect
glucose.

Bioreceptor:A molecule that specifically recognizes the analyte

*Enzymes, cells, aptamers,etc

Bio recognition:
the interaction of the bioreceptor with the analyte

which can be converted to make signals by the transducer

21
Q

what is a transducer in biorecptor

A

an element that converts one form of energy into
another.

role of the transducer is to convert the
bio-recognition event into a measurable signal

process of energy conversion =>
signalisation

produce either optical or electrical signals that are
usually proportional to size of analyte–bioreceptor
interactions

works in a physicochemical way: optical, piezoelectric,
electrochemical,(et c) resulting from the interaction of the analyte with the biological element, to easily
measure and quantify.

22
Q

electronics, and what is display

A

part of a biosensor that processes the transduced signal
and prepares it for display.
consists of complex electronic circuitry such that
signal amplification, signals from
analogue into the digital form.

The processed signals are then quantified by the display unit of
the biosensor

display:
consists of a user interpretation system such as the
LCD of a computer or a direct printer that generates numbers or curves understandable by the user

consists of a combination of hardware and software that generates results of the biosensor in a user-friendly manner.

The output signal on the display can be numeric, graphic, tabular
or an image`

23
Q

biosensors classification

and inventor of first bio sensor

A

based on bioreceptors, transducers, detection system, based on technology

developed by Leland C. Clark in
1956 for oxygen detection. his invention of the oxygen electrode
bears his name: ‘Clark electrode

24
Q

static and dynamic attributes that every bio sensor has

A

Selectivity(most imp):
the ability of a bioreceptor to detect a specific analyte in a
sample containing other admixtures /contaminants.
Reproducibility
the ability of the biosensor to generate identical
responses for a duplicated experimental set-up.
is characterised by the precision and accuracy of the
transducer and electronics in a biosensor

Precision is the ability of the sensor to provide alike in a sample

and accuracy indicates the sensor’s capacity to provide a mean value close to true value of sample

Stability
degree of susceptibility to ambient disturbances; can cause a drift in the output signals (measurement) causing an error in the measured
concentration and affects the precision and accuracy

sensitivity
The minimum amount of analyte that can be detected by a biosensor
defines its limit of detection (LOD) or sensitivity.
concentration of as low ng/ml,fg/ml to confirm the presence of traces of analytes

Linearity
attribute that shows the accuracy of the measured
response (for a set of measurements with different concentrations of
analyte) into a straight line
c (concentration anyate), y (output signal),
m (sensitivity) of the biosensor.

*Linearity of the biosensor is => resolution of the
biosensor and range of analyte concentrations under test.
*The resolution of the biosensor is the smallest change in the
concentration of an analyte =change in response of the biosensor.

25
Q

portable electrochemical biosensing devices

A

Portable blood glucose meter
= handheld
electrochemical detector and
disposable test strips. The test
strip contains a bottom
electrode layer, an adhesive
spacer layer and a hydrophilic
cover layer. The blood sample is
introduced to the reaction
chamber by capillary force.

26
Q

wearable electrochemical biosensor

A

Wearable sensors
can be applied to
monitor
health-related or
disease related
analytes in different
body fluids, including
tears, saliva and
sweat.

Health
management can be based on continuous
monitoring using
wearable devices,

27
Q

3D bio printing process

A
  • image gaining via CT, MRI or ultrasound
  • make 3D models
    material(polymers, ceramics, and bioactive components) and component selection
    -cell type (bioink singular/multiple
    cell types) selection
    -Bioprinting
    -static or dynamic incubation
    -implantation

Bio printing
haversting cells via cell cultures
cell materials(bio ink and bio paper=> bio printer)

Scaffolds =>
(adjust printing parameters construct printing)

organ developoment =>bioreacter, Bio printed Tissue

28
Q

inkjet,Microextrusion, Laser assisted,
stereolithography bioprinter

A

inkjet: heat bubble which propels bio-ink out of the nozzle or piezo electric which makes acoustic waves that propel the bioink out

stereolithography:
photopolymorisation occurs on the surface where light sensitive bio ink is exposed to light energy, the axail platform moves downward during fabrication, layer-layer technique depends on height and not on complexity

,Microextrusion:
pneumatic-based, right to left mechanical based,exerts mechanical pressure through micro-nozzles, can produce structures with great mechanical properties and print fidelity