bio chem quiz 1: plasma proteins

Question 1

What are B lymphocytes?

Answer 1

White blood cells that produce immunglobulins/antibodies . develop in bone marrow

Question 2

What is the primary difference between plasma and serum?

Answer 2

Plasma contains protein and clotting factors, whereas serum does not contain fibrinogen or clotting factors.

Question 3

Plasma protein characteristics:

Answer 3

mostly synthesized in the liver, generally synthesized on membrane bound polysomes (RER), have a half life , can be altered, may exhibit polymorphisms, most are glycoproteins

Question 4

what will lead to a decrease in serum protein levels?

Answer 4

nephrotic syndrome, malabsorption, starvation, blood loss

Question 5

what will lead to an increase in serum protein levels?

Answer 5

dehydration, multiple myeloma

Question 6

How do antibodies bind to antigens?

Answer 6

with high affinity (low Kd) and high specificity . combine non covalently with antigens .

Question 7

Antibody structure/img structure

Answer 7

2 H, 2 light, amino terminal contain variable regions where diversity resides ,

Question 8

which biochemical feature differentiates the five classes of ImG?

Answer 8

the constant region of the heavy chain dictates cell interactions. 5 classes differ in heavy chains

Question 9

where is the antigen binding sites?

Answer 9

variable regions near the amino terminus of the heavy and light chains

Question 10

what are antigenic sites?

Answer 10

areas at the N terminus of H and L chains that form beta sheets
loops are hypervariable and are significant to antigenic sites.