Biliary Secretion

Question 1

Canines have what kind of gallbladder?

Answer 1

single gallbladder

Question 2

Felines have what kind of gallbladder?

Answer 2

double gallbladder (sometimes single)

Question 3

Explain the difference in biliary ductal anatomy between canine and feline

Answer 3

canine: separate bile duct and pancreatic duct
feline: bile duct and pancreatic duct merge to form common bile duct

Question 4

Name the 4 anatomic units of biliary secretion

Answer 4

hepatocytes
canaliculi
ductules
ducts

Question 5

What is the composition of bile salts?

Answer 5

bile salts
water
electrolytes
cholesterol
phospholipids
bilirubin
hormones
protein

Question 6

Name the 3 functions of biliary secretion

Answer 6

1. excretory route of drugs and metabolites
2. HCO3 for acid neutralization
3. bile salts for fat digestion and absorption

Question 7

Name the 4 components that regulate biliary secretion

Answer 7

acetylcholine (gallbladder)
cholecystokinin (gallbladder, sphincter of Oddi)
secretin (bile duct)
bile salts (bile duct)

Question 8

What is bile acid?

Answer 8

steroid 4-ring structure with hydroxyl groups

changes from: cholic acid - deoxycholic acid - lithocholic acid

Question 9

How do cats conjugate bile acid?

Answer 9

cats are obligate taurine conjugators

Question 10

How do dogs conjugate bile acid?

Answer 10

dogs primarily conjugate with taurine but can also use glycine

Question 11

Name the 2 ways that bile salts digest and absorb fat

Answer 11

emulsification

micellarization

Question 12

Explain enterohepatic re-circulation of bile salts

Answer 12

bile salts are reabsorbed by a specialized mucosa in the terminal ileum
bile salts are carried in portal venous blood to liver