Bile Metabolism/ Liver Flashcards
What is the mechanism of bile micelle formation around lipids?
Bile salts surround lipids—emulsify(make into little droplets that increase surface area)—Biles salts+ Pancreatic lipase (activated by trypsin) + Co-lipase(binds with hydrophilic heads of bile so pancreatic lipase can get in through to the bile/lipid—hydrolysis for lipase—micelle contained digested lipids—presents to entercoyte where bile exit and diffuses into cell
What is bile and where is it synthesized, secreted, and stored?
Bile is an alkaline fluid that aids in fat emulsification and transport.
synthesized: liver that bile canniculi (collects secreted bile)–hepatic duct
Stored: Gall bladder
Whats are side illeal resection?
- more serious
- loss of bile recycling, -means we are loosing bile in the feces
- increase in motility through the intestinal tract will cause severe diarrhea
Treatment: Chloestryramine
bind to bile and prevent some of osmotic features
low-fat diet
What is of bilirubin?
end product from of heme breakdown
What happens when we take out the gall bladder laproscopically ? cholecystectomy?
- no serious effect
- surgery usually works well
- can halt recycling due to increase in liver synthesis of bile secretion causing a back up in liver
- possible diarhhea
What is the mechanism of bilirubin breakdown?
Bilirubin is drawn out with the bile, bacteria will convert bilirubin into urobilinogen—which is then converted then stercobilin (green/brownish color) into feces and recycled back to liver where it is secreted in the urine—(yellow color)
What are the two fates of biliriubin digestion?
- Final conversion to stercobilin and excretion in brown feces
- Recycling of urobilinogen and final excretion in urine yellow
What are the 7 functions of the liver?
1.Regulation of Protein, carbohydrate, and lipid metabolism
2.Regulation of cholesterol production and excretion
3.-Oxidation of fatty acids
4Bile acid production
5Degradation of hormones
6.Detoxification and excretion of drugs and toxins
7.Vitamin storage
What percent of cardiac output goes to the liver?
~25%
1.5 L/min
What is portal hypertension?
increased blood pressure in any vasculature of liver blood supply
What are 2 complications cause pre-hepatic portal hypertension?
- Portal V thrombosis
2. Congenital atresia
What are 3 complications cause intra-hepatic portal hypertension ?
- cirrhosisis
- fibrosis
- wilsons’d
What are 3 complications cause post- hepatic portal hypertension?
- Any obstruction between the liver and right heart
- Thrombosis
- CHF
- pericarditits
Where is lymph drained from the liver?
Space of disse and it then drains into venous blood
What are the 3 most common unusual symptoms of of impaired blood flow to the liver?
- Ascites
- Hepatomealy
- Jaundice