Bile acid sequestrants

Question 1

MoA

Answer 1

Binds to and sequesters bile acids.
Liver then produces more bile acids to replace those lost.
Body uses cholesterol to make bile acids = reduced LDL cholesterol circulating in the blood.

Question 2

Initiation

Answer 2

Must be initiated by a specialist

Question 3

Examples

Answer 3

Colesevelam
Colestipol
Colestyramine

Question 4

Interactions

Answer 4

Impairs absorption of fat-soluble vitamins (ADEK) and other drugs

Question 5

Administration

Answer 5

Take other drugs 1 hour before (4 hours for colesevelam) or 4 hours after bile sequestrant.