Bile Flashcards
1
Q
What is bile made from?
A
Cholesterol
2
Q
What is the enzyme for making primary bile acids?
A
7 alpha hydroxylase
3
Q
what is the difference between a primary and secondary bile acid?
A
Primary - Synthesised by liver
Secondary - Made by bacterial action
4
Q
What is the process of conjugation?
A
From cholesterol you get cholic acid or chenodeoxycholic acid. These are primary and can be conjugated with glycine or taurine.
They can leave unconjugated and by made into secondary by bacteria - deoxycholic acid or lithocolic. These can then also be conjugated.
TWO Cs FIRST
5
Q
Why are bile acids conjugated?
A
It makes them ampipathic so then can bind fat and take them to brush borders for absorption
6
Q
What is in bile?
A
Bilirubin, bile acids, bile salts
