Bilateral temporal damage ->hippocampus

Question 1

Amnesia occurred after some cases of (thin, HM)

Answer 1

unilateral temporal lobectomy that was used to treat epilepsy - now do WADA testing

Question 2

Hippocampus vulnerability to damage: Case reports of patients with cardiac arrest and anoxia

Answer 2

were amnestic - at autopsy CA1 “was gone”

Question 3

Why is CA1 so susceptible to anoxia, seizures, hypoglycemia?

Answer 3

Many neurons in hippo have NMDA receptors and metabolic disturbances of various kinds cause release of glutamate that activates NMDA receptors that allow Ca+ to enter and destroy neuron

Question 4

If animals are pretreated with NMDA blockers,

Answer 4

anoxia is much less likely to produce brain damage

Question 5

Many NMDA neurons make it easy to

Answer 5

establish long-term potentiation that allows fast learning, but also makes the area vulnerable to self-destruction when metabolic disruptions occur