BIGUANIDES, DYES, HEAVY METALS, PRESERVATIVES Flashcards
Alexidine, Chlorhexidine, Hexitidine
Biguanides
broad spectrum antibacterial but not effective against acid fast, spores and virus
Biguanides
Hibiclens, Orahex, GynePro
Chlorhexidine gluconate
originally tested as antimalarial
Chlorhexidine gluconate
antifungal (vaginal)
anthelmintic (oral)
Gentian Violet
antifungal for ringworm and athlete’s foot
Basic Fuchsin
weak antiseptic for cystitis and urethritis
Methylene Blue
inhibition/killing of microorganisms by using of very small amount of a chemical substance
Oligodynamic action
MOA: combination of metal ions with -SH groups
Oligodynamic action
Use: antiseptic, preservative, diuretic
MOA: covalent bond with -SH group
Mercury
Toxicity of Mercury
Minamata Disease (ataxia, muscle weakness numbness, narrowing field of vision)
Use: 1% soln as ophthalmic antiseptic, antibacterial for burns
Silver
Silver toxicity
Argyria (treatment NaCl)
prevention of neonatal conjunctivitis
2% aqueous soln of silver nitrate
Treatment of opthalmia neonatorum
Silver (Argyrol, Collarhol, Protargol, Silver sulfadiazine)
Use: prevention of algae in pools and fish tank
Application: meat products
Copper
Toxicity of Copper
Wilson’s disease (Tx Penicillamine)
Tx for dandruff (anti fungal)
Selenium
metal that is antiseptic mouthwash
Zinc
Preservatives in:
Cosmetics
Bread
Acidic preparations
Parabens
Calcium propionate
Sorbic and Benzoic acid
MOA: metabolic inhibition in fungal cells
Organic acids
MOA: inhibition of certain iron-containing enzymes of anaerobes
Nitrates, Nitrites
Use: Prevent growth C. botulinum in food and imparts a red color
Nitrates and Nitrites
Salitre
Potassium nitrate
Potassium nitrate + hemoglobin=
pinkish color on meat products
-anti fungal
-low toxicity due to rapid hydrolysis in vivo
-preservative for liquid DF
P-hydroxybenzoic acid derivatives
methylparaben, propylparaben, butylparaben, ethylparaben
P-hydroxybenzoic acid derivatives