Biguanide: Metformin --> MoA in description Flashcards
decreased hepatic glucose production, increased insulin sensitivty, decreased intestinal absorption of glucose
1
Q
Metformin*
Brand
Dose (maintenance & max)
How to decrease GI upset
BBW
CI
Which vitamin to monitor?
SE
Decreases A1C by?
Effect on weight?
Any hypoglycemia?
D/D/I
A
- Glucophage, Glucophage XR, Fortamet,
Glumetza*, Riomet - IR: 500 mg daily* or BID
- Titrate weekly, usual maintenance dose: 1,000 mg BID
- Max: 2,000-2550 mg/day
- give with a meal to decrease GI upset
- BBW: lactic acidosis
- CI: eGFR < 30, metabolic acidosis (including DKA)
- Vitamin B12 deficiency
- symptoms include peripheral
neuropathy, cognitive impairment, - SE: transient GI effects
- Decreases A1C by 1-2%
- Effect on weight: none
- Any hypoglycemia: no
-D/D/I: Iodine contrast dye, alcohol, topiramate
