Big picture of neuroepidemiology

Question 1

Difference between genetics and genomics

Answer 1

genetics- study of selected genes to understand inheritance

Genomics-Study of the whole genome to understand how variations affect health and disease

Question 2

What clinical manifestations does epilepsy have

Answer 2

Hypersynchronous neuronal discharge

Question 3

Clinical presentations of Parkinsons

Answer 3

Tremor

Bradykinesia (slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions)

Rigidity and Gait disorders

Postural instability not caused by primary visual, vestibular, cerebellar or proprioceptive dysfunction

Question 4

What is Myasthenia graves

Answer 4

Autoimmune disorder of the neuromuscular junction

Question 5

What is a Myasthenic crisis

Answer 5

Medical emergency characterised by neuromuscular respiratory failure

Spontaneous or precipitated by infection, surgery or medication

Question 6

Symptoms of myasthenia graves

Answer 6

Weakness of eye muscles
Ptosis - (drooping of eye muscles)
Diplopia (blurred or double vision)
Change in facial expression
SOB
Dysarthria (impaired speech)

Question 7

What is Guillain Barre syndrome

Answer 7

Acute immune-mediated polyneuropathy

• Progressive muscle weakness
• Reduced or absent tendon reflexes
• From mind weakness to complete paralysis of limb, facial, respiratory and bulbar muscles
• Autonomic nervous system dysfunction

Question 8

How is Guillain Barre syndrome seen in labs

Answer 8

Elevated spinal fluid protein with normal cell count

Question 9

How is Guillain Barre syndrome treated

Answer 9

IVIG

Plasma exchange

Question 10

What is DALY

Answer 10

1 DALY is not year lost due to ill-health disability or early death